Choi Haesun, Ma Jingfei
Department of Diagnostic Radiology, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd., Box Unit 368, Houston, TX 77030, USA.
AJR Am J Roentgenol. 2008 Apr;190(4):1055-9. doi: 10.2214/AJR.07.2998.
The purpose of this study was to evaluate the utility of perfluorocarbon (PFC) compound compared with air in the endorectal coil in improving the quality of conventional MR spectroscopy of the prostate.
A total of 62 consecutively registered patients were selected. MR spectroscopy of the prostate was performed with PFC in the endorectal coil for 34 of the patients and with air for 28. In the cases of 13 of the 28 patients, MR spectroscopy was repeated with a PFC-filled endorectal coil. The spectral line widths and the spectral separations from MR spectroscopy with an air-filled endorectal coil were compared with those obtained with a PFC-filled coil.
In all 62 patients, the mean line width values were reduced, from 13.3 +/- 3.0 Hz with air to 7.3 +/- 2.0 Hz with PFC (p = 0.0001, Student's t test). In 13 patients who underwent MR spectroscopy with air followed by MR spectroscopy with PFC, the mean line width values were reduced, from 14.8 +/- 3.4 Hz with air to 7.0 +/- 1.5 Hz with PFC (p = 0.0001, Student's t test). In 72 voxels analyzed for spectral separation, clear separations between the choline, polyamine, and creatine peaks were found in 57 voxels with PFC and four with air. Better splitting of the citrate peaks was found in 35 voxels with PFC and one with air.
The use of PFC compound in the endorectal coil is a safe and cost-effective way to consistently generate high-quality prostate MR spectroscopic results and to substantially improve quantitation of prostatic metabolites. These improvements should increase the diagnostic value of MR spectroscopy in the care of patients with prostate cancer.
本研究旨在评估直肠内线圈中全氟化碳（PFC）化合物与空气相比，在改善前列腺常规磁共振波谱质量方面的效用。
共选取62例连续登记的患者。34例患者在直肠内线圈中使用PFC进行前列腺磁共振波谱检查，28例使用空气。在28例患者中的13例中，使用充满PFC的直肠内线圈重复进行磁共振波谱检查。将使用充满空气的直肠内线圈进行磁共振波谱检查的谱线宽度和谱分离与使用充满PFC的线圈获得的结果进行比较。
在所有62例患者中，平均线宽值降低，从使用空气时的13.3±3.0Hz降至使用PFC时的7.3±2.0Hz（p = 0.0001，Student t检验）。在13例先使用空气进行磁共振波谱检查，然后使用PFC进行检查的患者中，平均线宽值降低，从使用空气时的14.8±3.4Hz降至使用PFC时的7.0±1.5Hz（p = 0.0001，Student t检验）。在分析谱分离的72个体素中，在57个使用PFC的体素和4个使用空气的体素中发现胆碱、多胺和肌酸峰之间有明显分离。在35个使用PFC的体素和1个使用空气的体素中发现柠檬酸盐峰的更好分离。
在直肠内线圈中使用PFC化合物是一种安全且经济有效的方法，可始终如一地产生高质量的前列腺磁共振波谱结果，并显著改善前列腺代谢物的定量分析。这些改进应会增加磁共振波谱在前列腺癌患者护理中的诊断价值。
