Siahanidou Tania, Margeli Alexandra, Lazaropoulou Christina, Karavitakis Emanouil, Papassotiriou Ioannis, Mandyla Helen
Neonatal Unit, First Department of Pediatrics, Athens University Medical School, "Aghia Sophia" Children's Hospital, Athens, 11527, Greece.
Pediatr Res. 2008 Apr;63(4):428-32. doi: 10.1203/PDR.0b013e31816780e4.
Adiponectin has potent insulin-sensitizing effects, improves lipid metabolism, and potentially protects against the development of metabolic syndrome. Thus, increasing adiponectin levels in preterm infants at risk for developing metabolic syndrome may be of special interest. The aim of this study was to examine the effects of dietary long-chain polyunsaturated fatty acids (LCPUFA) on serum adiponectin and lipid concentrations in preterm infants. Adiponectin and lipid levels of 60 healthy preterm infants [gestational age 32.7 (1.9) wk] randomly assigned to be fed either 1) a formula containing LCPUFA [arachidonic and docosahexanoic] (+LCPUFA group) or 2) the same formula without LCPUFA (-LCPUFA/control group), were determined at mean (SD) 33.8 (11.7) d. Adiponectin and HDL-C concentrations were significantly higher in the +LCPUFA group than in controls (p = 0.002 and p = 0.01, respectively); whereas, triglyceride levels were lower (p = 0.06). Adiponectin correlated positively with HDL-C levels and negatively with triglyceride levels in the +LCPUFA group but not in the controls. In conclusion, circulating adiponectin concentrations were higher in preterm infants fed a formula containing LCPUFA than infants fed an LCPUFA-free formula and they correlated with lipidemic profile.
脂联素具有强大的胰岛素增敏作用，可改善脂质代谢，并可能预防代谢综合征的发生。因此，提高有患代谢综合征风险的早产儿的脂联素水平可能会引起特别关注。本研究的目的是探讨膳食长链多不饱和脂肪酸（LCPUFA）对早产儿血清脂联素和脂质浓度的影响。对60名健康早产儿[胎龄32.7（1.9）周]进行随机分组，分别喂食1）含LCPUFA[花生四烯酸和二十二碳六烯酸]的配方奶（+LCPUFA组）或2）不含LCPUFA的相同配方奶（-LCPUFA/对照组），并在平均（标准差）33.8（11.7）天时测定脂联素和脂质水平。+LCPUFA组的脂联素和高密度脂蛋白胆固醇（HDL-C）浓度显著高于对照组（分别为p = 0.002和p = 0.01）；而甘油三酯水平较低（p = 0.06）。在+LCPUFA组中，脂联素与HDL-C水平呈正相关，与甘油三酯水平呈负相关，但在对照组中无此相关性。总之，喂食含LCPUFA配方奶的早产儿的循环脂联素浓度高于喂食不含LCPUFA配方奶的婴儿，且与血脂谱相关。
