Neonatal Unit, First Department of Pediatrics, Athens University Medical School, "Aghia Sophia" Children's Hospital, 11527 Athens, Greece.
Metabolism. 2011 Mar;60(3):389-93. doi: 10.1016/j.metabol.2010.03.002. Epub 2010 Mar 31.
The adipokine visfatin has been proposed to exert insulin-mimicking effects and to play a role in the development of metabolic syndrome. Preterm infants are at risk for the later development of insulin resistance and, possibly, for other components of metabolic syndrome. Dietary long-chain polyunsaturated fatty acids (LCPUFAs) during the perinatal period may reduce the risk of metabolic syndrome. The authors' objective was to study the circulating concentrations of visfatin in preterm infants and to examine associations of visfatin with anthropometric measurements, metabolic indices, and dietary LCPUFAs. Serum visfatin concentrations were determined by enzyme-linked immunosorbent assay at mean (SD) 33.8 (11.7) days of life in 60 healthy preterm infants (gestational age, 32.7 [1.9] weeks) randomly assigned to be fed since birth either a formula containing LCPUFA (arachidonic and docosahexaenoic acid) (+LCPUFA group) or the same formula without LCPUFA (-LCPUFA group). Associations of visfatin with anthropometric parameters, serum glucose, insulin, homeostasis model assessment index of insulin resistance, blood lipids, and adiponectin levels were examined. Serum visfatin levels were significantly higher in the +LCPUFA than in the -LCPUFA group (P < .001) and correlated positively with body weight z score (β = 0.31, P = .02), total cholesterol (β = 0.34, P = .01), high-density lipoprotein cholesterol (HDL-C) (β = 0.47, P < .001), and adiponectin levels (β = 0.29, P = .03), but not with indices of insulin sensitivity. In multiple regression analysis, HDL-C and dietary LCPUFAs correlated independently with serum visfatin levels. Circulating visfatin levels in preterm infants are independently associated with HDL-C levels and dietary LCPUFAs. Whether the higher visfatin levels in the +LCPUFA preterm infant group are beneficial for the later health of these infants remains to be determined.
亲脂细胞因子内脂素被认为具有胰岛素模拟作用，并在代谢综合征的发生发展中发挥作用。早产儿有发生胰岛素抵抗的风险，可能还有其他代谢综合征的成分。围生期长链多不饱和脂肪酸（LCPUFA）的饮食可能会降低代谢综合征的风险。作者的目的是研究早产儿循环中内脂素的浓度，并研究内脂素与人体测量指标、代谢指数和饮食 LCPUFA 的关系。在 60 名健康早产儿（胎龄 32.7±1.9 周）中，于平均（SD）33.8±11.7 天龄时通过酶联免疫吸附试验测定血清内脂素浓度，这些早产儿随机分为出生后即喂食含 LCPUFA（花生四烯酸和二十二碳六烯酸）配方（+LCPUFA 组）或不含 LCPUFA 的相同配方（-LCPUFA 组）。检查内脂素与人体测量参数、血清葡萄糖、胰岛素、胰岛素抵抗的稳态模型评估指数、血脂和脂联素水平的关系。+LCPUFA 组的血清内脂素水平显著高于-LCPUFA 组（P＜0.001），与体重 z 评分呈正相关（β=0.31，P=0.02），与总胆固醇（β=0.34，P=0.01）、高密度脂蛋白胆固醇（HDL-C）（β=0.47，P＜0.001）和脂联素水平（β=0.29，P=0.03）呈正相关，但与胰岛素敏感性指数无关。多元回归分析显示，HDL-C 和饮食 LCPUFA 与血清内脂素水平独立相关。早产儿循环中的内脂素水平与 HDL-C 水平和饮食 LCPUFA 独立相关。+LCPUFA 早产儿组中较高的内脂素水平是否对这些婴儿的后期健康有益仍有待确定。
