Siahanidou Tania, Mandyla Helen, Papassotiriou Gerasimos-Peter, Papassotiriou Ioannis, Chrousos George
First Department of Pediatrics, Athens University Medical School, Aghia Sophia Children's Hospital, 115 27 Athens, Greece.
Arch Dis Child Fetal Neonatal Ed. 2007 Jul;92(4):F286-90. doi: 10.1136/adc.2006.106112. Epub 2006 Oct 30.
To determine circulating levels of adiponectin in preterm infants and examine possible associations with anthropometric measurements, weight gain, and leptin and insulin levels.
Prospective study.
A university hospital neonatal care unit.
62 preterm (mean (SD) gestational age 32.0 (2.1) weeks) and 15 full-term infants (reference group).
Blood samples taken at discharge (40.9 (14.8) days of life) from the preterm infants and at a comparable postnatal age in full-term infants. All infants were fed the same commercial formula, but in nine preterms the formula contained long-chain polyunsaturated fatty acids (LCPUFAs).
Serum levels of adiponectin, leptin and insulin. Associations of adiponectin levels were tested only in the preterm group.
Serum levels of adiponectin were lower in preterm (40.9 (14.8) microg/ml) than full-term infants (53.1 (16.0) microg/ml, p<0.01). However, after adjustment for body weight, the influence of prematurity on adiponectin levels was no longer significant. In preterm infants, adiponectin levels independently correlated with being born small for gestational age (SGA) (beta=-0.35, p=0.01), weight gain (beta=0.28, p=0.03) and LCPUFA-supplemented formula (beta=0.34, p=0.009). Serum adiponectin levels did not correlate with insulin or leptin levels. However, insulin levels were higher in preterm than in full-term infants after adjustment for body weight.
Adiponectin levels are lower in preterm infants at discharge than full-term infants probably due to decreased adiposity. The levels are influenced by being born SGA, weight gain and, possibly, by dietary LCPUFAs. The importance of these findings in the development of insulin or leptin resistance in children born prematurely needs to be further studied.
测定早产儿脂联素的循环水平，并研究其与人体测量指标、体重增加以及瘦素和胰岛素水平之间的可能关联。
前瞻性研究。
大学医院新生儿重症监护病房。
62名早产儿（平均（标准差）胎龄32.0（2.1）周）和15名足月儿（对照组）。
早产儿在出院时（出生后40.9（14.8）天）采血，足月儿在相当于出院时的产后年龄采血。所有婴儿均喂食相同的商业配方奶，但9名早产儿的配方奶中含有长链多不饱和脂肪酸（LCPUFAs）。
血清脂联素、瘦素和胰岛素水平。脂联素水平的关联仅在早产儿组中进行检测。
早产儿血清脂联素水平（40.9（14.8）μg/ml）低于足月儿（53.1（16.0）μg/ml，p<0.01）。然而，在调整体重后，早产对脂联素水平的影响不再显著。在早产儿中，脂联素水平与小于胎龄儿（SGA）出生（β=-0.35，p=0.01）、体重增加（β=0.28，p=0.03）和补充LCPUFA的配方奶（β=0.34，p=0.009）独立相关。血清脂联素水平与胰岛素或瘦素水平无关。然而，在调整体重后，早产儿的胰岛素水平高于足月儿。
出院时早产儿的脂联素水平低于足月儿，可能是由于肥胖程度降低。这些水平受SGA出生、体重增加以及可能受膳食LCPUFAs的影响。这些发现在早产儿胰岛素或瘦素抵抗发展中的重要性需要进一步研究。
