Chen Shusen, Wang Yinong, Fan Yunge, Ma Jianbiao
Key Laboratory of Functional Polymer Materials (Ministry of Education), Institute of Polymer Chemistry, Department of Chemistry, Nankai University, Tianjin 300071, China.
J Biomed Mater Res A. 2009 Mar 1;88(3):769-77. doi: 10.1002/jbm.a.31909.
Amphiphilic biodegradable polyester, poly(tetraethylene glycol succinate) (PTEGSuc), was synthesized via melt polycondensation of tetraethylene glycol and succinic acid on catalysis of p-toluenesulfonic acid. It was observed that PTEGSuc could self-assemble into micelles in water. In addition, thermosensitivity of PTEGSuc aggregation in water was first found in the experiment, and the critical aggregation temperatures could be controlled by solution concentration. Transmission electron microscopy was used to investigate the micellar morphologies of PTEGSuc in different solvents. It was found that particle shape is almost round although the micellar morphology is different depending on the solvent used. Based on the perfect properties, especially in micelle formation and thermosensitivity, PTEGSuc is promising in biomedical field as carrier of drug delivery system, scaffold of tissue engineering, and other medical devices.
两亲性可生物降解聚酯聚（四甘醇琥珀酸酯）（PTEGSuc）通过对甲苯磺酸催化下四甘醇与琥珀酸的熔融缩聚反应合成。观察到PTEGSuc在水中可自组装成胶束。此外，实验中首次发现了PTEGSuc在水中聚集的热敏感性，且临界聚集温度可通过溶液浓度控制。利用透射电子显微镜研究了PTEGSuc在不同溶剂中的胶束形态。发现尽管胶束形态因所用溶剂不同而有所差异，但颗粒形状几乎为圆形。基于其优良性能，尤其是在胶束形成和热敏感性方面，PTEGSuc在生物医学领域作为药物递送系统的载体、组织工程支架及其他医疗设备具有广阔前景。
