Drescher K M, Tracy S M
Department of Medical Microbiology and Immunology, Creighton University School of Medicine, Omaha, NE 68178, USA
Curr Top Microbiol Immunol. 2008;323:259-74. doi: 10.1007/978-3-540-75546-3_12.
The origins of type 1 diabetes (T1D) are largely unknown. Fewer than 50% of the cases of the disease are attributable to host genetics, indicating that environmental factors are involved in disease development. The most often cited environmental agents implicated as initiators of T1D are the human enteroviruses, in particular the group B coxsackieviruses (CVB). Although the connection between the CVB and T1D has not been firmly established, significant' evidence supports the role of these pathogens in T1D development.
1型糖尿病（T1D）的病因在很大程度上尚不清楚。该疾病中不到50%的病例可归因于宿主基因，这表明环境因素参与了疾病的发展。最常被认为是引发T1D的环境因素是人类肠道病毒，尤其是B组柯萨奇病毒（CVB）。尽管CVB与T1D之间的联系尚未得到确凿证实，但大量证据支持这些病原体在T1D发展中的作用。
