Tracy S, Gauntt C
Department of Pathology and Microbiology, University of Nebraska, 986495 Nebraska Medical Center, Omaha, NE 68198, USA.
Curr Top Microbiol Immunol. 2008;323:49-63. doi: 10.1007/978-3-540-75546-3_3.
That which is understood of virulence phenotypes in the picornaviruses derives in large part from studies of artificially attenuating phenotypes rather than through examination of naturally occurring virus strains. The CVB replicate well in a variety of different murine and human cell cultures, making them excellent viruses with which to engage the problem of how the host environment interacts with specific viral genetics to promote varying efficiencies of viral replication. It is not known how highly virulent CVB strains may arise but evidence suggests such strains are not the norm.
在小核糖核酸病毒中，关于毒力表型的认识很大程度上源于对人工减毒表型的研究，而非通过对自然存在的病毒株的检测。柯萨奇病毒B（CVB）能在多种不同的小鼠和人类细胞培养物中良好复制，这使其成为研究宿主环境如何与特定病毒基因相互作用以促进不同病毒复制效率问题的理想病毒。目前尚不清楚高毒力的CVB毒株是如何产生的，但有证据表明这类毒株并非普遍存在。
