Wu Diana H, McMurtrie Daniel G, Hirsch Samuel D, Johnston Carolyn M
Department of Obstetrics and Gynecology, Saint Joseph Mercy Hospital, Ann Arbor, Michigan, USA.
J Reprod Med. 2008 Feb;53(2):141-4.
Mature, benign cystic teratomas of the ovary are common in reproductive-age women, but they are very rarely associated with androgen production and subsequent development of hirsutism or virilization. We describe a case of postmenopausal hirsutism and hyperandrogenism caused by a mature cystic teratoma as well as the 7 previously reported cases.
A 55-year-old, postmenopausal woman presented with hirsutism and unilateral lower extremity edema. Pelvic ultrasound showed a complex cystic mass in the left ovary measuring 6.0 x 7.0 x 10 cm, and laboratory evaluations revealed progressively increasing testosterone levels. The patient underwent total abdominal hysterectomy and bilateral salpingo-oophorectomy, with resection of a large, complex mass originating in the left ovary. The pathology department found 2 left, mature ovarian cystic teratomas containing a layer of Leydig cells. Postoperatively the patient experienced rapid normalization of the elevated testosterone level.
Although rare, ovarian production of androgens resulting in hirsutism or virilization can occur with a hormonally active mature cystic teratoma.
成熟的卵巢良性囊性畸胎瘤在育龄期女性中很常见，但它们很少与雄激素产生以及随后的多毛症或男性化发展相关。我们描述了一例由成熟囊性畸胎瘤引起的绝经后多毛症和高雄激素血症病例以及之前报道的7例病例。
一名55岁的绝经后女性出现多毛症和单侧下肢水肿。盆腔超声显示左卵巢有一个6.0×7.0×10 cm的复杂囊性肿块，实验室检查显示睾酮水平逐渐升高。患者接受了全腹子宫切除术和双侧输卵管卵巢切除术，切除了起源于左卵巢的一个大的复杂肿块。病理科发现左侧有2个成熟的卵巢囊性畸胎瘤，其中含有一层Leydig细胞。术后患者睾酮水平升高迅速恢复正常。
虽然罕见，但具有激素活性的成熟囊性畸胎瘤可导致卵巢产生雄激素，进而引起多毛症或男性化。
