Khandelia Himanshu, Ipsen John H, Mouritsen Ole G
MEMPHYS-Center for Biomembrane Physics, Department of Physics and Chemistry, University of Southern Denmark, Campusvej 55, Odense M, Denmark.
Biochim Biophys Acta. 2008 Jul-Aug;1778(7-8):1528-36. doi: 10.1016/j.bbamem.2008.02.009. Epub 2008 Mar 2.
We review the fundamental strategies used by small peptides to associate with lipid membranes and how the different strategies impact on the structure and dynamics of the lipids. In particular we focus on the binding of amphiphilic peptides by electrostatic and hydrophobic forces, on the anchoring of peptides to the bilayer by acylation and prenylation, and on the incorporation of small peptides that form well-defined channels. The effect of lipid-peptide interactions on the lipids is characterized in terms of lipid acyl-chain order, membrane thickness, membrane elasticity, permeability, lipid-domain and annulus formation, as well as acyl-chain dynamics. The different situations are illustrated by specific cases for which experimental observations can be interpreted and supplemented by theoretical modeling and simulations. A comparison is made with the effect on lipids of trans-membrane proteins. The various cases are discussed in the context of the possible roles played by lipid-peptide interactions for the biological, physiological, and pharmacological function of peptides.
我们回顾了小肽与脂质膜结合所使用的基本策略，以及不同策略如何影响脂质的结构和动力学。特别地，我们关注两亲性肽通过静电和疏水作用力的结合、肽通过酰化和异戊二烯化锚定到双层膜上，以及形成明确通道的小肽的掺入。脂质 - 肽相互作用对脂质的影响通过脂质酰基链顺序、膜厚度、膜弹性、通透性、脂质域和环带形成以及酰基链动力学来表征。通过具体案例说明了不同情况，对于这些案例，实验观察结果可以通过理论建模和模拟进行解释和补充。并与跨膜蛋白对脂质的影响进行了比较。在脂质 - 肽相互作用对肽的生物学、生理学和药理学功能可能发挥的作用的背景下，讨论了各种情况。
