Cummings Sue, Apovian Caroline M, Khaodhiar Lalita
MGH Weight Center, Massachusetts General Hospital, Boston, MA 02114, USA.
J Am Diet Assoc. 2008 Apr;108(4 Suppl 1):S40-4. doi: 10.1016/j.jada.2008.01.017.
Obesity is associated with an increased risk of developing insulin resistance and type 2 diabetes. Development of type 2 diabetes can be delayed or sometimes prevented from manifestation in individuals with obesity that are able to lose weight. Weight loss can be achieved either medically with behavioral therapies that combine diet and exercise treatment or with behavioral therapies combined with weight-loss medications or weight-loss surgery. There is strong evidence of an amelioration or resolution of type 2 diabetes in patients undergoing gastric bypass surgery. A recently published retrospective cohort study indicated that long-term total mortality from diabetes, heart disease, and cancer after gastric bypass surgery was substantially reduced. In this review, we summarize the evidence of surgical interventions in the treatment of type 2 diabetes.
肥胖与发生胰岛素抵抗和2型糖尿病的风险增加相关。对于能够减重的肥胖个体，2型糖尿病的发生可以延迟，有时甚至可以预防其显现。减重可以通过结合饮食和运动治疗的行为疗法在医学上实现，也可以通过结合减重药物或减重手术的行为疗法来实现。有强有力的证据表明，接受胃旁路手术的患者的2型糖尿病得到改善或缓解。最近发表的一项回顾性队列研究表明，胃旁路手术后糖尿病、心脏病和癌症导致的长期总死亡率大幅降低。在本综述中，我们总结了手术干预治疗2型糖尿病的证据。
