Hospices Civils de Lyon, Inserm U 870, Inra 1235, Université de Lyon1, France.
Diabetes Metab. 2009 Dec;35(6 Pt 2):562-3. doi: 10.1016/S1262-3636(09)73466-4.
Surgical treatment of morbid obesity has been shown to be efficient for long-term weight loss and to improve obesity-related complications. The improvement of type 2 diabetes (T2DM) is dependent of the type of surgery, and is more frequent with gastric bypass than with gastric band. Normalization of glucose metabolism is rapid, often occurring before weight loss, and shown to be related to both a decrease in insulin resistance and an increase in insulin secretion. Some factors limiting the efficiency of gastric bypass on T2DM is the duration of diabetes and the residual beta-cell mass. However, a decrease in diabetes-related death has been found in a large series of surgical cases. These data constitute a good argument for proposing surgery in T2DM obese patients as soon as possible. Nevertheless, whether or not this suggests changing the usual indications for bariatric surgery in T2DM patients, such as a body mass index (BMI) score of<35 kg/m(2), remains controversial.
手术治疗病态肥胖症已被证明可长期有效减轻体重,并改善肥胖相关并发症。手术类型影响 2 型糖尿病(T2DM)的改善情况,胃旁路手术比胃带手术更常见。葡萄糖代谢的正常化是迅速的,往往在体重减轻之前发生,并且与胰岛素抵抗的降低和胰岛素分泌的增加有关。胃旁路手术对 T2DM 的效率有限的一些因素是糖尿病的持续时间和剩余的β细胞质量。然而,在大量的手术病例中发现,糖尿病相关死亡有所减少。这些数据为尽快向 T2DM 肥胖患者提出手术建议提供了有力论据。然而,这是否意味着改变 T2DM 患者接受减重手术的常用指征,例如 BMI<35 kg/m(2),仍存在争议。
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