Ott R J, Brada M, Flower M A, Babich J W, Cherry S R, Deehan B J
Department of Physics, Royal Marsden Hospital, Sutton, Surrey, U.K.
Eur J Cancer. 1991;27(11):1356-61. doi: 10.1016/0277-5379(91)90009-3.
Positron emission tomography (PET) has been used to measure changes in regional blood-brain barrier (BBB) permeability in patients with primary cerebral lymphoma undergoing radiotherapy and chemotherapy. The method employed is to measure the rate of wash-out of a radioactive tracer (68Ga-EDTA) from blood into brain tissue using time-sequence PET imaging. Preliminary studies carried out on patients with more common primary cerebral tumours show that time-activity data are reproducible to approximately 10%. Measurements made in 2 patients with primary cerebral lymphoma treated with initial chemotherapy showed significant changes in permeability in the region of the tumour. Within 5 weeks of the start of treatment, permeability values reached the levels of normal brain. No changes in BBB permeability in normal brain were seen immediately after radiotherapy.
正电子发射断层扫描（PET）已被用于测量接受放疗和化疗的原发性脑淋巴瘤患者局部血脑屏障（BBB）通透性的变化。所采用的方法是使用时间序列PET成像来测量放射性示踪剂（68Ga-EDTA）从血液进入脑组织的洗脱速率。对患有更常见原发性脑肿瘤的患者进行的初步研究表明，时间-活性数据的重现性约为10%。对2例接受初始化疗的原发性脑淋巴瘤患者进行的测量显示，肿瘤区域的通透性有显著变化。在治疗开始后的5周内，通透性值达到了正常脑的水平。放疗后立即观察到正常脑的血脑屏障通透性没有变化。
