用[68Ga]乙二胺四乙酸和正电子发射断层扫描检查阿尔茨海默型痴呆患者的血脑屏障通透性。

Examination of blood-brain barrier permeability in dementia of the Alzheimer type with [68Ga]EDTA and positron emission tomography.

作者信息

Schlageter N L, Carson R E, Rapoport S I

出版信息

J Cereb Blood Flow Metab. 1987 Feb;7(1):1-8. doi: 10.1038/jcbfm.1987.1.

DOI:10.1038/jcbfm.1987.1

Abstract

Positron emission tomography with [68Ga]ethylenediaminetetraacetic acid ([68Ga]EDTA) was used to examine the integrity of the blood-brain barrier (BBB) in five patients with dementia of the Alzheimer type and in five healthy age-matched controls. Within a scanning time of 90 min, there was no evidence that measurable intravascular tracer entered the brain in either the dementia or the control group. An upper limit for the cerebrovascular permeability-surface area product of [68Ga]EDTA was estimated as 2 X 10(-6) s-1 in both groups. The results provide no evidence for breakdown of the BBB in patients with dementia of the Alzheimer type.

摘要

采用[68Ga]乙二胺四乙酸（[68Ga]EDTA）正电子发射断层扫描技术，对5例阿尔茨海默型痴呆患者及5名年龄匹配的健康对照者的血脑屏障（BBB）完整性进行了检测。在90分钟的扫描时间内，无论是痴呆组还是对照组，均未发现有可测量的血管内示踪剂进入脑内的证据。两组中[68Ga]EDTA的脑血管通透表面积乘积上限估计均为2×10^(-6) s^(-1)。结果表明，阿尔茨海默型痴呆患者不存在血脑屏障破坏的证据。