Pozzilli C, Bernardi S, Mansi L, Picozzi P, Iannotti F, Alfano B, Bozzao L, Lenzi G L, Salvatore M, Conforti P
Department of Neurological Sciences, University of Rome La Sapienza, Italy.
J Neurol Neurosurg Psychiatry. 1988 Aug;51(8):1058-62. doi: 10.1136/jnnp.51.8.1058.
Fifteen patients with definite multiple sclerosis were examined with high volume delayed (HVD) CT scan and positron emission tomography (PET) using 68-Ga-EDTA as a tracer. The passage of 68-Ga-EDTA across the blood-brain barrier (BBB) was measured by using multiple graphical analysis. This method permits the simultaneous calculation of a blood to brain influx constant Ki (ml/g-1 min-1) and of the plasma volume Vp (ml/g-1). Focal areas of abnormal CT enhancement and pathological accumulation of 68-Ga-EDTA were visualised in four patients who were all examined during a clinical exacerbation of the disease. The mean Ki value measured in these areas was 12.5, SD 3.4 indicating a moderate but significant increase of BBB permeability compared with the value found in normal tissue (3.2, SD 0.9). No parallel increase in Vp values was found in these pathological areas. Quantitative data obtained with PET seems to provide further insight into the study of BBB function in multiple sclerosis.
对15例确诊为多发性硬化症的患者进行了大容量延迟（HVD）CT扫描和正电子发射断层扫描（PET），使用68-Ga-EDTA作为示踪剂。通过多次图形分析测量68-Ga-EDTA穿过血脑屏障（BBB）的情况。该方法允许同时计算血脑流入常数Ki（ml/g-1 min-1）和血浆体积Vp（ml/g-1）。在4例患者中观察到CT增强异常的局灶性区域和68-Ga-EDTA的病理性积聚，这4例患者均在疾病临床加重期接受检查。在这些区域测得的平均Ki值为12.5，标准差为3.4，表明与正常组织中的值（3.2，标准差0.9）相比，血脑屏障通透性有中度但显著的增加。在这些病理区域未发现Vp值有平行增加。PET获得的定量数据似乎为多发性硬化症血脑屏障功能的研究提供了进一步的见解。
