Weisenthal L M, Kern D H
Oncotech, Inc. Irvine, California.
Oncology (Williston Park). 1991 Sep;5(9):93-103; disc. 104, 111-4, 117-8.
In the opinion of the authors, good medical practice demands the avoidance of ineffective therapies and good cancer chemotherapy generally demands the avoidance of inactive drugs. The authors present their viewpoint that randomized trials are not required to prove that physicians should not administer inactive drugs and that existing cell culture assays are acceptably accurate in identifying inactive drugs. They describe and advocate the use of two such tests to aid in choosing between different forms of therapy that would otherwise be equally acceptable in the absence of test information. Strengths, weaknesses, and applications of the assays are discussed.
作者认为，良好的医疗实践要求避免使用无效疗法，而良好的癌症化疗通常要求避免使用无活性的药物。作者提出他们的观点，即无需进行随机试验来证明医生不应使用无活性药物，并且现有的细胞培养试验在识别无活性药物方面具有可接受的准确性。他们描述并提倡使用两种此类测试，以帮助在不同治疗形式之间进行选择，否则在没有测试信息的情况下这些治疗形式将同样可以接受。讨论了这些试验的优点、缺点和应用。
