Andreotti P E, Linder D, Hartmann D M, Cree I A, Pazzagli M, Bruckner H W
BATLE LE, Inc., Fort Lauderdale, FL 33334.
J Biolumin Chemilumin. 1994 Nov-Dec;9(6):373-8. doi: 10.1002/bio.1170090604.
The BATLE LE TCA-100 tumour chemosensitivity assay has been used to evaluate chemotherapeutic drug sensitivity of cultured tumour cell lines. Studies were performed using test drug concentrations calibrated to discriminate sensitivity and resistance of clinical specimens. Strong sensitivity which appeared to be inconsistent with clinical experience was detected for some drugs and cell lines. Findings of strong sensitivity were consistent with basic differences between sensitivity testing cultured cell lines and clinical specimens. Results with cell lines frequently may not apply directly to clinical applications. Characterization of differences between cell lines and clinical specimens may assist in application of cell line findings to clinical trials.
BATLE LE TCA - 100肿瘤化疗敏感性检测已用于评估培养的肿瘤细胞系的化疗药物敏感性。研究使用校准的测试药物浓度进行，以区分临床标本的敏感性和耐药性。对于某些药物和细胞系，检测到了与临床经验似乎不一致的强敏感性。强敏感性的结果与培养的细胞系敏感性测试和临床标本之间的基本差异一致。细胞系的结果通常可能无法直接应用于临床。表征细胞系和临床标本之间的差异可能有助于将细胞系研究结果应用于临床试验。
