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正常压力脑积水步态中对轻敲试验反应最敏感的特征。

Features of gait most responsive to tap test in normal pressure hydrocephalus.

作者信息

Ravdin Lisa D, Katzen Heather L, Jackson Anna E, Tsakanikas Diamanto, Assuras Stephanie, Relkin Norman R

机构信息

Department of Neurology and Neuroscience, New York Presbyterian Hospital, Weill Medical College of Cornell University, Cornell Memory Disorders Program, 428 East 72 Street, Suite 500, New York, NY 10021, United States.

出版信息

Clin Neurol Neurosurg. 2008 May;110(5):455-61. doi: 10.1016/j.clineuro.2008.02.003. Epub 2008 Mar 21.

DOI:10.1016/j.clineuro.2008.02.003
PMID:18359152
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2690636/
Abstract

OBJECTIVE

To identify components of gait associated with a positive tap test (TT) in patients with idiopathic normal pressure hydrocephalus (iNPH).

PATIENTS AND METHODS

Thirty-three patients with iNPH underwent clinical evaluation pre- and post-TT and were classified as responders (Rs) or non-responders (NRs). Elements of gait were assessed with a formal standardized Gait Scale and compared between groups.

RESULTS

Analysis of pre/post-TT group differences revealed an interaction for Total Gait Score and Walking Score, with improvements in responders only. Total Gait Scores improved by 29% in the Rs and 4.85% in the NRs. Rs showed significant post-TT improvements on a timed 10m walk, turning, and balance. Tandem walking, turning, truck balance and start stop hesitation showed trends toward improvement.

CONCLUSIONS

The classic features of gait often used in determining diagnosis of NPH (wide based stride, reduced foot-floor clearance, and small steps) were not helpful in identifying responders to the TT. Walking speed, steps for turning, and tendency towards falling were most likely to improve post-TT. These straightforward measures can readily be adapted into clinical practice to assist in determination of shunt candidacy.

摘要

目的

确定特发性正常压力脑积水(iNPH)患者中与阳性叩击试验(TT)相关的步态组成部分。

患者与方法

33例iNPH患者在TT前后接受临床评估,并分为反应者(Rs)或无反应者(NRs)。采用正式的标准化步态量表评估步态要素,并在组间进行比较。

结果

TT前后组间差异分析显示,总步态评分和步行评分存在交互作用,仅反应者有改善。反应者的总步态评分提高了29%,无反应者提高了4.85%。反应者在定时10米步行、转身和平衡方面TT后有显著改善。串联步行、转身、躯干平衡和起停犹豫有改善趋势。

结论

常用于确定NPH诊断的经典步态特征(宽基步态、足部离地间隙减小和步幅小)对识别TT反应者无帮助。步行速度、转身步数和跌倒倾向在TT后最有可能改善。这些简单的测量方法可很容易地应用于临床实践,以协助确定分流手术的候选者。

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本文引用的文献

1
Dutch normal pressure hydrocephalus study: baseline characteristics with emphasis on clinical findings.荷兰常压脑积水研究:基线特征,重点是临床发现。
Eur J Neurol. 1997 Jan;4(1):39-47. doi: 10.1111/j.1468-1331.1997.tb00297.x.
2
Gait disturbance in normal pressure hydrocephalus: a clinical study.正常压力脑积水的步态障碍:一项临床研究。
Parkinsonism Relat Disord. 2007 Oct;13(7):434-7. doi: 10.1016/j.parkreldis.2006.08.007. Epub 2006 Oct 17.
3
The value of supplemental prognostic tests for the preoperative assessment of idiopathic normal-pressure hydrocephalus.补充性预后测试在特发性正常压力脑积水术前评估中的价值。
Neurosurgery. 2005 Sep;57(3 Suppl):S17-28; discussion ii-v. doi: 10.1227/01.neu.0000168184.01002.60.
4
Diagnosing idiopathic normal-pressure hydrocephalus.诊断特发性正常压力脑积水。
Neurosurgery. 2005 Sep;57(3 Suppl):S4-16; discussion ii-v. doi: 10.1227/01.neu.0000168185.29659.c5.
5
Normal pressure hydrocephalus: survey on contemporary diagnostic algorithms and therapeutic decision-making in clinical practice.正常压力脑积水:临床实践中当代诊断算法与治疗决策的调查。
Acta Neurochir (Wien). 2004 Apr;146(4):379-88; discussion 388. doi: 10.1007/s00701-004-0234-3. Epub 2004 Feb 27.
6
Predictors of outcome in patients with normal-pressure hydrocephalus.正常压力脑积水患者预后的预测因素
Eur Neurol. 2004;51(2):59-67. doi: 10.1159/000075345. Epub 2003 Dec 4.
7
Comparison between the lumbar infusion and CSF tap tests to predict outcome after shunt surgery in suspected normal pressure hydrocephalus.腰椎灌注试验与脑脊液穿刺试验在预测疑似正常压力脑积水分流术后结果方面的比较。
J Neurol Neurosurg Psychiatry. 2002 Dec;73(6):721-6. doi: 10.1136/jnnp.73.6.721.
8
The value of temporary external lumbar CSF drainage in predicting the outcome of shunting on normal pressure hydrocephalus.临时体外腰椎脑脊液引流在预测正常压力脑积水分流结果中的价值。
J Neurol Neurosurg Psychiatry. 2002 Apr;72(4):503-6. doi: 10.1136/jnnp.72.4.503.
9
Idiopathic normal pressure hydrocephalus: a systematic review of diagnosis and outcome.特发性正常压力脑积水:诊断与预后的系统评价
Neurosurgery. 2001 Nov;49(5):1166-84; discussion 1184-6. doi: 10.1097/00006123-200111000-00028.
10
Gait analysis in idiopathic normal pressure hydrocephalus--which parameters respond to the CSF tap test?特发性正常压力脑积水的步态分析——哪些参数对脑脊液引流试验有反应?
Clin Neurophysiol. 2000 Sep;111(9):1678-86. doi: 10.1016/s1388-2457(00)00362-x.