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与结核分枝杆菌感染相关的炎性假瘤。

Inflammatory pseudotumor associated with Mycobacterium tuberculosis infection.

作者信息

Androulaki Athina, Papathomas Thomas G, Liapis George, Papaconstantinou Ioannis, Gazouli Maria, Goutas Nikos, Bramis Konstantinos, Papalambros Alexandros, Lazaris Andreas C, Papalambros Efstathios

机构信息

1(st) Department of Pathology, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.

出版信息

Int J Infect Dis. 2008 Nov;12(6):607-10. doi: 10.1016/j.ijid.2007.12.011. Epub 2008 Mar 21.

Abstract

BACKGROUND

Inflammatory pseudotumor is a relatively rare entity; originally identified in the lung, it has been described in multiple extrapulmonary anatomic locations.

CASE REPORT

We report on the unusual case of an inflammatory pseudotumor associated with Mycobacterium tuberculosis infection, which was initially mistaken for a renal malignancy both in clinical and radiological settings. We additionally present three brief reviews concerning: (1) infectious agents postulated to induce morphological changes of an inflammatory pseudotumor; (2) mycobacterial pseudotumors; and (3) distinction from inflammatory myofibroblastic tumors of the renal pelvis.

CONCLUSIONS

The present case highlights the diagnostic importance of PCR-based detection of mycobacterial DNA in granulomatous tissue responses. It is of crucial importance that clinicians are aware of this unusual manifestation of mycobacterial infection to ensure that pertinent laboratory evaluation is employed and appropriate treatment is administered in order to avoid potential clinical implications.

摘要

背景

炎性假瘤是一种相对罕见的疾病;最初在肺部被发现,现已在多个肺外解剖部位被描述。

病例报告

我们报告了一例与结核分枝杆菌感染相关的炎性假瘤的罕见病例,该病例在临床和放射学检查中最初均被误诊为肾恶性肿瘤。我们还另外提供了三篇简短综述,内容涉及:(1)推测可诱导炎性假瘤形态改变的感染因子;(2)分枝杆菌假瘤;(3)与肾盂炎性肌纤维母细胞瘤的鉴别。

结论

本病例突出了基于聚合酶链反应检测肉芽肿组织反应中分枝杆菌DNA的诊断重要性。临床医生了解分枝杆菌感染的这种不寻常表现至关重要,以确保进行相关实验室评估并给予适当治疗,从而避免潜在的临床后果。

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