Granjeiro Ronaldo C, Kehrle Helga M, Bezerra Roberta L, Almeida Vanessa F, Sampaio André L L, Oliveira Carlos A
Secretaria de Saúde do Governo do Distrito Federal, Brasília, Brasil.
Otolaryngol Head Neck Surg. 2008 Apr;138(4):502-6. doi: 10.1016/j.otohns.2007.11.012.
To test the hypothesis that tinnitus begins with outer hair cell dysfunction by recording transient (TEOAE) and distortion product evoked (DPOAE) oto-acoustic emissions in patients with normal hearing with (study group, SG) and without tinnitus (control group, CG).
Case control study.
SG had 32 patients with pure tone thresholds below 25 dB in the 500 to 8000 Hz interval. CG had 37 age- and gender-matched patients with similar thresholds. All patients had normal tympanograms and stapedial reflexes. TEOAE were recorded with wide band click in continuous mode at 80-dB peak SPL. DPOAE were recorded with f1/f2 = 1.22 and intensities of 65 dB (f1) and 55 dB (f2) SPL.
DPOAE were abnormal in 68.4% of SG and in 50% of CG (P = 0.036). TEOAE were abnormal in 70.2% of SG and in 16.10% of CG (P = 0.0001).
SG had significantly higher prevalence of abnormal TEOAE and DPOAE than CG.
通过记录听力正常且伴有耳鸣的患者（研究组，SG）和不伴有耳鸣的患者（对照组，CG）的瞬态耳声发射（TEOAE）和畸变产物耳声发射（DPOAE），来验证耳鸣始于外毛细胞功能障碍这一假设。
病例对照研究。
研究组有32例患者，其纯音听阈在500至8000赫兹区间低于25分贝。对照组有37例年龄和性别匹配、听阈相似的患者。所有患者的鼓室图和镫骨肌反射均正常。TEOAE采用宽带短声在80分贝峰值声压级连续模式下记录。DPOAE采用f1/f2 = 1.22，f1强度为65分贝声压级，f2强度为55分贝声压级记录。
研究组中68.4%的患者DPOAE异常，对照组中50%的患者DPOAE异常（P = 0.036）。研究组中70.2%的患者TEOAE异常，对照组中16.10%的患者TEOAE异常（P = 0.0001）。
研究组中TEOAE和DPOAE异常的患病率显著高于对照组。
