Lieberman J
Ann N Y Acad Sci. 1976;278:488-97. doi: 10.1111/j.1749-6632.1976.tb47061.x.
Elevation of serum-angiotensin-converting enzyme (serum ACE) in patients with active sarcoidosis was confirmed in a total of 64 subjects with a mean serum ACE of 15.76+/-7.4 units compared with 6.05+/-2.0 units in 194 patients with other types of respiratory disease. Resolution of the sarcoidosis disease state or therapeutic control with adequate doses of corticosteroids (15 mg prednisone daily) brought the elevated serum ACE levels down into the normal range. A longitudinal study of serum ACE activity was found to be an effective way of judging the therapeutic efficacy of various steroid dosage levels. No other disease state involved in the differential diagnosis of sarcoidosis was found to have elevations of serum ACE activity. However, 6 patients with Gaucher's disease did have elevated serum ACE activity that ranged well above the usual level seen even in patients with sarcoidosis. The two diseases could be readily distinguished in the laboratory by elevated serum acid phosphatase activity in most cases of Gaucher's disease. It would appear that detection of elevated serum ACE levels can be a useful procedure for confirming a diagnosis of active sarcoidosis and for judging the therapeutic response.
在总共64例结节病活动期患者中，血清血管紧张素转换酶（血清ACE）升高得到证实，这些患者的血清ACE平均为15.76±7.4单位，而194例其他类型呼吸系统疾病患者的血清ACE为6.05±2.0单位。结节病病情缓解或用足量皮质类固醇（每日15mg泼尼松）治疗控制后，升高的血清ACE水平降至正常范围。血清ACE活性的纵向研究被发现是判断各种类固醇剂量水平治疗效果的有效方法。在结节病鉴别诊断中涉及的其他疾病状态均未发现血清ACE活性升高。然而，6例戈谢病患者确实有血清ACE活性升高，其水平远高于即使是结节病患者中常见的水平。在大多数戈谢病病例中，这两种疾病在实验室中可通过血清酸性磷酸酶活性升高轻易区分。似乎检测血清ACE水平升高对于确诊结节病活动期和判断治疗反应可能是一种有用的方法。
