Silverstein E, Friedland J, Lyons H A
Isr J Med Sci. 1977 Oct;13(10):1001-6.
The elevated activity of serum angiotensin converting enzyme (ACE) in sarcoidosis was usually reduced during steroid therapy but remained above the normal value (52 nmol-min-1-ml-1) in approximately a third of patients during the first year of therapy. ACE was elevated in 5 of 10 patients treated with steroids for at least four years. It was significantly higher in untreated patients (placebo group), who were subsequently placed on steroid therapy because of clinical deterioration, than in those remaining on placebo therapy. In general ACE tended to diminish with increasing duration of disease. The results suggest that serial study of ACE may be useful in the clinical management of sarcoidosis, including assessment of the degree of activity, the need for steroid therapy, therapeutic result and the prognosis.
结节病患者血清血管紧张素转换酶（ACE）活性升高，在类固醇治疗期间通常会降低，但在治疗的第一年，约三分之一的患者仍高于正常值（52纳摩尔·分钟⁻¹·毫升⁻¹）。接受类固醇治疗至少四年的10名患者中有5名ACE升高。未接受治疗的患者（安慰剂组）因临床病情恶化随后接受类固醇治疗，其ACE水平显著高于继续接受安慰剂治疗的患者。一般来说，ACE往往会随着疾病持续时间的延长而降低。结果表明，对ACE进行系列研究可能有助于结节病的临床管理，包括评估活动程度、类固醇治疗的必要性、治疗效果和预后。
