含正磷酸钙颗粒的功能性牙科复合材料的组成边界。
Compositional boundaries for functional dental composites containing calcium orthophosphate particles.
机构信息
University of São Paulo School of Dentistry, Department of Biomaterials and Oral Biology, Av. Prof. Lineu Prestes, 2227, São Paulo, SP, 05508-000, Brazil.
Oregon Health & Science University School of Dentistry, Department of Oral Rehabilitation and Integrative Biosciences, Division of Biomaterials and Biomedical Sciences, 2730 S Moody Ave, Portland, OR, 97201, USA.
出版信息
J Mech Behav Biomed Mater. 2023 Aug;144:105928. doi: 10.1016/j.jmbbm.2023.105928. Epub 2023 Jun 7.
OBJECTIVES
To investigate the interrelationships among handling, degree of conversion (DC), mechanical behavior and Ca release of composites containing dicalcium phosphate dihydrate (DCPD, CaHPO.2HO), as a function of total inorganic content and DCPD: glass ratio.
METHODS
Twenty-one formulations (1 BisGMA: 1 TEGDMA, in mols) with inorganic fractions ranging from zero to 50 vol% and different DCPD: glass ratios were evaluated for viscosity (parallel plate rheometer, n = 3), DC (near-FTIR spectroscopy, n = 3), fracture toughness/K (single-edge notched beam, n = 7-11) and 14-day Ca release (inductively coupled plasma optical emission spectroscopy, n = 3). Data were analyzed by ANOVA/Tukey test (except viscosity, where Kruskal-Wallis/Dunn tests were used, α: 0.05).
RESULTS
Viscosity and DC increased with DCPD: glass ratio among composites with the same inorganic content (p < 0.001). At inorganic fractions of 40 vol% and 50 vol%, keeping DCPD content at a maximum of 30 vol% did not compromise K. Ca release showed an exponential relationship with DCPD mass fraction in the formulation (R = 0.986). After 14 days, a maximum of 3.8% of the Ca mass in the specimen was released.
CONCLUSION
Formulations containing 30 vol% DCPD and 10-20 vol% glass represent the best compromise between viscosity, K and Ca release. Materials with 40 vol% DCPD should not be disregarded, bearing in mind that Ca release will be maximized at the expense of K
目的
研究二水磷酸氢钙（DCPD，CaHPO·2H2O）作为复合材料总无机含量和 DCPD：玻璃比例函数的含量、转化率（DC）、机械性能和 Ca 释放之间的相互关系。
方法
评估了 21 种配方（1BisGMA：1TEGDMA，摩尔比），其无机部分从 0 到 50vol%，DCPD：玻璃比例不同，用于粘度（平行板流变仪，n=3）、DC（近红外光谱，n=3）、断裂韧性/K（单边缺口梁，n=7-11）和 14 天 Ca 释放（电感耦合等离子体发射光谱，n=3）。数据通过方差分析/Tukey 检验进行分析（除了粘度，使用 Kruskal-Wallis/Dunn 检验，α：0.05）。
结果
在具有相同无机含量的复合材料中，DCPD：玻璃比例与粘度和 DC 呈正相关（p<0.001）。在 40vol%和 50vol%的无机分数下，保持 DCPD 含量最大为 30vol%，不会影响 K。Ca 释放与配方中 DCPD 质量分数呈指数关系（R=0.986）。14 天后，释放的最大 Ca 质量为 3.8%。
结论
含有 30vol%DCPD 和 10-20vol%玻璃的配方在粘度、K 和 Ca 释放之间达到了最佳平衡。应考虑含有 40vol%DCPD 的材料，尽管 K 会降低，但 Ca 释放会最大化。
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