Lee Hang Lak, Eun Chang Soo, Lee Oh Young, Jeon Yong Cheol, Sohn Ju Hyun, Han Dong Soo, Yoon Byung Chul, Choi Ho Soon, Hahm Joon Soo, Lee Min Ho, Lee Dong Hoo
Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea.
J Clin Gastroenterol. 2008 Jul;42(6):672-5. doi: 10.1097/MCG.0b013e31806daf64.
To date, many studies have reported on the association of obesity with gastroesophageal reflux disease (GERD), although none of these have been systematic. In light of this, we conducted this study to examine the association of obesity and GERD.
A total of 3363 patients underwent gastroscopy at Hanyang University Health Promotion Center. Among these patients, we prospectively examined patients who were diagnosed with GERD-related erosive esophagitis on endoscopy.
Multivariate analysis showed that the significant risk factors were waist-to-hip ratio (WHR), hiatal hernia, body mass index (BMI), and smoking. As compared with patients who had a WHR less than 0.8, the multivariate odds ratio for erosive esophagitis were 4.055 for a WHR more than 1.0 and 2.316 for a WHR of 0.8 to 1.0. As compared with patients who had a BMI of 20 to 22.5, the multivariate odds ratio for erosive esophagitis was 3.308 (95% confidence interval, 1.792 to 6.107) for a BMI greater than 30.
Obesity, especially abdominal obesity, was the significant risk factor for erosive esophagitis.
迄今为止，许多研究报道了肥胖与胃食管反流病（GERD）之间的关联，尽管这些研究均未进行系统分析。鉴于此，我们开展了本研究以探讨肥胖与GERD之间的关联。
共有3363例患者在汉阳大学健康促进中心接受了胃镜检查。在这些患者中，我们对在内镜检查中被诊断为GERD相关糜烂性食管炎的患者进行了前瞻性研究。
多因素分析显示，显著的危险因素包括腰臀比（WHR）、食管裂孔疝、体重指数（BMI）和吸烟。与腰臀比小于0.8的患者相比，腰臀比大于1.0的患者发生糜烂性食管炎的多因素比值比为4.055，腰臀比为0.8至1.0的患者为2.316。与BMI为20至22.5的患者相比，BMI大于30的患者发生糜烂性食管炎的多因素比值比为3.308（95%置信区间为1.792至6.107）。
肥胖，尤其是腹型肥胖，是糜烂性食管炎的重要危险因素。
