Ther Clin Risk Manag. 2006 Jun;2(2):219-26. doi: 10.2147/tcrm.2006.2.2.219.
Estimate the costs and benefits of influenza vaccination in a group of employees of an Italian District Health Authority, Unità Locale Socio Sanitaria (ULSS), to define a scheme of an economic evaluation to be used for other vaccination strategies.
In an observational study conducted from December 2002 to April 2003, 107 ULSS employees, voluntarily vaccinated, were compared with 107 nonvaccinated ULSS employees matched for age, sex, and job category. The outcome of cost-benefit analysis was evaluated by checking personnel department records about absences from work and their causes, including influenza. Costs and benefits of the influenza vaccination from the ULSS point of view were calculated.
The influenza vaccination strategy reduced absences from work by 23% and decreased the loss of working days by 30% and related cost. This difference is not significative. The ratio vaccination benefits/cost was euro4.2. The advantage of vaccination is confirmed by sensitivity analysis performed on the mean cost of a working day, which showed that the benefit-cost ratio ranged from euro4.5 to euro11.7.
The results suggest that the influenza vaccination strategy in our sample of people was cost-saving. The economic evaluation used in this study could also be used for other vaccination strategies and in other settings.
评估意大利地区卫生局（Unità Locale Socio Sanitaria，ULSS）一组员工接种流感疫苗的成本和收益，为其他疫苗接种策略制定经济评估方案。
在 2002 年 12 月至 2003 年 4 月进行的一项观察性研究中，107 名自愿接种疫苗的 ULSS 员工与 107 名年龄、性别和工作类别匹配的未接种 ULSS 员工进行了比较。通过检查人事部门关于工作缺勤及其原因（包括流感）的记录，评估成本效益分析的结果。
流感疫苗接种策略使缺勤率降低了 23%，减少了 30%的工作日损失和相关成本。这一差异无统计学意义。从 ULSS 的角度来看，疫苗接种的效益成本比为 4.2。敏感性分析针对每个工作日的平均成本进行，结果显示效益成本比在 4.5 欧元至 11.7 欧元之间，这证实了疫苗接种的优势。
研究结果表明，在我们的研究人群中，流感疫苗接种策略具有成本效益。本研究中使用的经济评估也可用于其他疫苗接种策略和其他环境。
