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ABHD6是一种未注释的α/β水解酶超家族成员,在癌细胞系中差异表达。

An unannotated alpha/beta hydrolase superfamily member, ABHD6 differentially expressed among cancer cell lines.

作者信息

Li Fan, Fei Xiangwei, Xu Jiaxi, Ji Chaoneng

机构信息

State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Science, Fudan University, Shanghai, 200433, P.R. China.

出版信息

Mol Biol Rep. 2009 Apr;36(4):691-6. doi: 10.1007/s11033-008-9230-7. Epub 2008 Mar 22.

DOI:10.1007/s11033-008-9230-7
PMID:18360779
Abstract

Abhydrolase domain containing (Abhd) gene was a small group belongs to alpha/beta hydrolase superfamily. Known members of this group are all found to be involved in important biochemical processes and related to various diseases. In this paper, we report the tissue distribution, subcellular location and differential distribution among cancer cell lines of Abhd6, one unannotated member of this group.

摘要

含水解酶结构域(Abhd)基因是属于α/β水解酶超家族的一个小家族。该家族已知成员均被发现参与重要的生化过程并与多种疾病相关。在本文中,我们报道了该家族一个未注释成员Abhd6在组织中的分布、亚细胞定位以及在癌细胞系中的差异分布。

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An unannotated alpha/beta hydrolase superfamily member, ABHD6 differentially expressed among cancer cell lines.ABHD6是一种未注释的α/β水解酶超家族成员,在癌细胞系中差异表达。
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Serine Hydrolases in Lipid Homeostasis of the Placenta-Targets for Placental Function?丝氨酸水解酶在胎盘脂质稳态中的作用——胎盘功能的靶点?

本文引用的文献

1
Elevated mature macrophage expression of human ABHD2 gene in vulnerable plaque.人ABHD2基因在易损斑块中成熟巨噬细胞的表达升高。
Biochem Biophys Res Commun. 2008 Jan 11;365(2):207-13. doi: 10.1016/j.bbrc.2007.10.127. Epub 2007 Oct 31.
2
A functional proteomic strategy to discover inhibitors for uncharacterized hydrolases.一种用于发现未知水解酶抑制剂的功能蛋白质组学策略。
J Am Chem Soc. 2007 Aug 8;129(31):9594-5. doi: 10.1021/ja073650c. Epub 2007 Jul 13.
3
Lipids changes in liver cancer.肝癌中的脂质变化。
Int J Mol Sci. 2022 Jun 20;23(12):6851. doi: 10.3390/ijms23126851.
4
Identification of Early-Onset Metastasis in SF3B1 Mutated Uveal Melanoma.SF3B1 突变型葡萄膜黑色素瘤中早期转移的鉴定
Cancers (Basel). 2022 Feb 8;14(3):846. doi: 10.3390/cancers14030846.
5
Alpha/Beta-Hydrolase Domain-Containing 6: Signaling and Function in the Central Nervous System.含α/β水解酶结构域蛋白6:在中枢神经系统中的信号传导与功能
Front Pharmacol. 2021 Dec 2;12:784202. doi: 10.3389/fphar.2021.784202. eCollection 2021.
6
α/β-Hydrolase Domain (ABHD) Inhibitors as New Potential Therapeutic Options against Lipid-Related Diseases.α/β-水解酶结构域(ABHD)抑制剂作为治疗与脂质相关疾病的新的潜在治疗选择。
J Med Chem. 2021 Jul 22;64(14):9759-9785. doi: 10.1021/acs.jmedchem.1c00624. Epub 2021 Jul 2.
7
Enhanced monoacylglycerol lipolysis by ABHD6 promotes NSCLC pathogenesis.ABHD6 通过增强单酰甘油脂肪酶水解促进 NSCLC 的发病机制。
EBioMedicine. 2020 Mar;53:102696. doi: 10.1016/j.ebiom.2020.102696. Epub 2020 Mar 3.
8
A Preliminary Investigation towards the Risk Stratification of Allogeneic Stem Cell Recipients with Respect to the Potential for Development of GVHD via Their Pre-Transplant Plasma Lipid and Metabolic Signature.关于异基因干细胞受体通过移植前血浆脂质和代谢特征发生移植物抗宿主病(GVHD)可能性的风险分层的初步研究。
Cancers (Basel). 2019 Jul 25;11(8):1051. doi: 10.3390/cancers11081051.
9
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10
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J Zhejiang Univ Sci B. 2007 Jun;8(6):398-409. doi: 10.1631/jzus.2007.B0398.
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5
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Increase of smooth muscle cell migration and of intimal hyperplasia in mice lacking the alpha/beta hydrolase domain containing 2 gene.缺乏含α/β水解酶结构域2基因的小鼠中平滑肌细胞迁移和内膜增生增加。
Biochem Biophys Res Commun. 2005 Apr 1;329(1):296-304. doi: 10.1016/j.bbrc.2005.01.127.
10
Images of interest. Hepatobiliary and pancreatic: Dorfman-Chanarin syndrome.
J Gastroenterol Hepatol. 2005 Jan;20(1):156. doi: 10.1111/j.1440-1746.2004.03752.x.