Giamarellou Helen, Kanellakopoulou Kyriaki
Athens University Medical School, Athens, Greece.
Crit Care Clin. 2008 Apr;24(2):261-78, viii. doi: 10.1016/j.ccc.2007.12.004.
Based on the worldwide prevalence of multidrug-resistant strains of Pseudomas aeruginosa and the fact that no newer antipseudomonal agents are available, this article aims to investigate therapeutic solutions for combating infections caused by P aeruginosa, including multidrug-resistant strains. The article focuses mainly on colistin, the re-emerging old antibiotic that possesses prominent antipseudomonal activity in vitro and on doripenem, a newer carbapenem that seems to be close to its global marketing. Regarding older antipseudomonal antibiotics that have been reviewed extensively, only newer aspects on their use are considered in this article.
鉴于全球范围内多重耐药铜绿假单胞菌菌株的流行情况,以及目前尚无更新的抗铜绿假单胞菌药物,本文旨在研究对抗铜绿假单胞菌(包括多重耐药菌株)感染的治疗方案。本文主要聚焦于黏菌素(一种重新受到关注的老抗生素,在体外具有显著的抗铜绿假单胞菌活性)和多黏菌素(一种较新的碳青霉烯类抗生素,似乎即将在全球上市)。对于已被广泛综述的老抗铜绿假单胞菌抗生素,本文仅考虑其使用方面的新情况。