is an opportunistic human pathogen that has become a nosocomial health problem worldwide. The pathogen has multiple drug removal and virulence secretion systems, is resistant to many antibiotics, and there is no commercial vaccine against it. is a zoonotic pathogen that is on the Select Agents list. The bacterium is the deadliest pathogen known to humans and antibiotic-resistant strains are appearing naturally. There is no commercial vaccine against the pathogen, either. In the current work, novel compounds based on metallacarborane cage were studied on strains of and a substitute, . The representative compounds had IC values below 10 µM against and values of 20-50 μM against . Artificial generation of compound-resistant suggested a common mechanism for drug resistance, the first reported in the literature, and suggested -linked metallacarboranes as impervious to cellular mechanisms of resistance generation. SEM analysis of the compound-resistant strains showed that the compounds had a predominantly bacteriostatic effect and blocked bacterial cell division in . The compounds could be a starting point towards novel anti- drugs and the strategy presented here proposes a mechanism to bypass any future drug resistance in bacteria.