模式甲虫及害虫赤拟谷盗的基因组。

The genome of the model beetle and pest Tribolium castaneum.

作者信息

Richards Stephen, Gibbs Richard A, Weinstock George M, Brown Susan J, Denell Robin, Beeman Richard W, Gibbs Richard, Beeman Richard W, Brown Susan J, Bucher Gregor, Friedrich Markus, Grimmelikhuijzen Cornelis J P, Klingler Martin, Lorenzen Marce, Richards Stephen, Roth Siegfried, Schröder Reinhard, Tautz Diethard, Zdobnov Evgeny M, Muzny Donna, Gibbs Richard A, Weinstock George M, Attaway Tony, Bell Stephanie, Buhay Christian J, Chandrabose Mimi N, Chavez Dean, Clerk-Blankenburg Kerstin P, Cree Andrew, Dao Marvin, Davis Clay, Chacko Joseph, Dinh Huyen, Dugan-Rocha Shannon, Fowler Gerald, Garner Toni T, Garnes Jeffrey, Gnirke Andreas, Hawes Alica, Hernandez Judith, Hines Sandra, Holder Michael, Hume Jennifer, Jhangiani Shalini N, Joshi Vandita, Khan Ziad Mohid, Jackson LaRonda, Kovar Christie, Kowis Andrea, Lee Sandra, Lewis Lora R, Margolis Jon, Morgan Margaret, Nazareth Lynne V, Nguyen Ngoc, Okwuonu Geoffrey, Parker David, Richards Stephen, Ruiz San-Juana, Santibanez Jireh, Savard Joël, Scherer Steven E, Schneider Brian, Sodergren Erica, Tautz Diethard, Vattahil Selina, Villasana Donna, White Courtney S, Wright Rita, Park Yoonseong, Beeman Richard W, Lord Jeff, Oppert Brenda, Lorenzen Marce, Brown Susan, Wang Liangjiang, Savard Joël, Tautz Diethard, Richards Stephen, Weinstock George, Gibbs Richard A, Liu Yue, Worley Kim, Weinstock George, Elsik Christine G, Reese Justin T, Elhaik Eran, Landan Giddy, Graur Dan, Arensburger Peter, Atkinson Peter, Beeman Richard W, Beidler Jim, Brown Susan J, Demuth Jeffery P, Drury Douglas W, Du Yu-Zhou, Fujiwara Haruhiko, Lorenzen Marce, Maselli Vincenza, Osanai Mizuko, Park Yoonseong, Robertson Hugh M, Tu Zhijian, Wang Jian-jun, Wang Suzhi, Richards Stephen, Song Henry, Zhang Lan, Sodergren Erica, Werner Doreen, Stanke Mario, Morgenstern Burkhard, Solovyev Victor, Kosarev Peter, Brown Garth, Chen Hsiu-Chuan, Ermolaeva Olga, Hlavina Wratko, Kapustin Yuri, Kiryutin Boris, Kitts Paul, Maglott Donna, Pruitt Kim, Sapojnikov Victor, Souvorov Alexandre, Mackey Aaron J, Waterhouse Robert M, Wyder Stefan, Zdobnov Evgeny M, Zdobnov Evgeny M, Wyder Stefan, Kriventseva Evgenia V, Kadowaki Tatsuhiko, Bork Peer, Aranda Manuel, Bao Riyue, Beermann Anke, Berns Nicola, Bolognesi Renata, Bonneton François, Bopp Daniel, Brown Susan J, Bucher Gregor, Butts Thomas, Chaumot Arnaud, Denell Robin E, Ferrier David E K, Friedrich Markus, Gordon Cassondra M, Jindra Marek, Klingler Martin, Lan Que, Lattorff H Michael G, Laudet Vincent, von Levetsow Cornelia, Liu Zhenyi, Lutz Rebekka, Lynch Jeremy A, da Fonseca Rodrigo Nunes, Posnien Nico, Reuter Rolf, Roth Siegfried, Savard Joël, Schinko Johannes B, Schmitt Christian, Schoppmeier Michael, Schröder Reinhard, Shippy Teresa D, Simonnet Franck, Marques-Souza Henrique, Tautz Diethard, Tomoyasu Yoshinori, Trauner Jochen, Van der Zee Maurijn, Vervoort Michel, Wittkopp Nadine, Wimmer Ernst A, Yang Xiaoyun, Jones Andrew K, Sattelle David B, Ebert Paul R, Nelson David, Scott Jeffrey G, Beeman Richard W, Muthukrishnan Subbaratnam, Kramer Karl J, Arakane Yasuyuki, Beeman Richard W, Zhu Qingsong, Hogenkamp David, Dixit Radhika, Oppert Brenda, Jiang Haobo, Zou Zhen, Marshall Jeremy, Elpidina Elena, Vinokurov Konstantin, Oppert Cris, Zou Zhen, Evans Jay, Lu Zhiqiang, Zhao Picheng, Sumathipala Niranji, Altincicek Boran, Vilcinskas Andreas, Williams Michael, Hultmark Dan, Hetru Charles, Jiang Haobo, Grimmelikhuijzen Cornelis J P, Hauser Frank, Cazzamali Giuseppe, Williamson Michael, Park Yoonseong, Li Bin, Tanaka Yoshiaki, Predel Reinhard, Neupert Susanne, Schachtner Joachim, Verleyen Peter, Raible Florian, Bork Peer, Friedrich Markus, Walden Kimberly K O, Robertson Hugh M, Angeli Sergio, Forêt Sylvain, Bucher Gregor, Schuetz Stefan, Maleszka Ryszard, Wimmer Ernst A, Beeman Richard W, Lorenzen Marce, Tomoyasu Yoshinori, Miller Sherry C, Grossmann Daniela, Bucher Gregor

机构信息

Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA.

出版信息

Nature. 2008 Apr 24;452(7190):949-55. doi: 10.1038/nature06784. Epub 2008 Mar 23.

DOI:10.1038/nature06784

PMID:18362917

Abstract

Tribolium castaneum is a member of the most species-rich eukaryotic order, a powerful model organism for the study of generalized insect development, and an important pest of stored agricultural products. We describe its genome sequence here. This omnivorous beetle has evolved the ability to interact with a diverse chemical environment, as shown by large expansions in odorant and gustatory receptors, as well as P450 and other detoxification enzymes. Development in Tribolium is more representative of other insects than is Drosophila, a fact reflected in gene content and function. For example, Tribolium has retained more ancestral genes involved in cell-cell communication than Drosophila, some being expressed in the growth zone crucial for axial elongation in short-germ development. Systemic RNA interference in T. castaneum functions differently from that in Caenorhabditis elegans, but nevertheless offers similar power for the elucidation of gene function and identification of targets for selective insect control.

摘要

赤拟谷盗是物种最为丰富的真核生物目成员之一，是研究昆虫普遍发育过程的强大模式生物，也是储藏农产品的重要害虫。我们在此描述其基因组序列。这种杂食性甲虫已经进化出与多样化学环境相互作用的能力，这体现在气味受体、味觉受体以及细胞色素P450和其他解毒酶的大量扩增上。与果蝇相比，赤拟谷盗的发育更能代表其他昆虫，这一事实在基因组成和功能上都有所体现。例如，与果蝇相比，赤拟谷盗保留了更多参与细胞间通讯的祖先基因，其中一些基因在短胚发育中对轴向伸长至关重要的生长区表达。赤拟谷盗中的系统性RNA干扰作用与秀丽隐杆线虫中的不同，但在阐明基因功能和确定选择性昆虫控制靶点方面仍具有相似的作用。