Greisler H P, Cabusao E B, Lam T M, Murchan P M, Ellinger J, Kim D U
Department of Surgery, Loyola University Medical Center, Maywood, Illinois 60153.
ASAIO Trans. 1991 Jul-Sep;37(3):M472-5.
This study compares the kinetics of collagen deposition within the prosthesis/tissue complexes formed following implantation of either polyglactin 910 (PG910), polydioxanone (PDS), or Dacron prostheses into rabbit infrarenal aortas. The grafts were explanted in triplicate at 1, 3, and 12 months, and then processed for spectrophotometric hydroxyproline quantitation. A 2 mm longitudinal strip from each sample was processed for histologic evaluation by light and electron microscopy. Results showed more extensive collagen deposition within the prosthesis/tissue complexes of both PG910 and PDS continuing throughout 3 months, as compared to less collagen deposition in Dacron grafts at all time points. Differences between PG910 and Dacron, and between PDS and Dacron at each time point were statistically significant. When correlated with previous related studies done in our laboratory, data showed that in resorbable grafts the rate of collagen deposition parallels the kinetics of cellular proliferation, tissue thickening, and graft resorption.
本研究比较了将聚乙交酯910（PG910）、聚二氧六环酮（PDS）或涤纶人工血管植入兔肾下腹主动脉后形成的人工血管/组织复合物中胶原蛋白沉积的动力学。在1、3和12个月时将移植物一式三份取出，然后进行分光光度法羟脯氨酸定量分析。从每个样本中取一条2毫米长的纵向条带，进行光镜和电镜组织学评估。结果显示，与涤纶移植物在所有时间点的胶原蛋白沉积较少相比，PG910和PDS的人工血管/组织复合物中的胶原蛋白沉积在整个3个月内更为广泛。PG910与涤纶、PDS与涤纶在每个时间点的差异具有统计学意义。当与我们实验室之前进行的相关研究相关联时，数据表明，在可吸收移植物中，胶原蛋白沉积速率与细胞增殖、组织增厚和移植物吸收的动力学平行。
