Potlukova E, Kralikova P
Third Clinic of Medicine, General Teaching Hospital, First Faculty of Medicine, Charles University, Prague, Czech Republic.
Scand J Immunol. 2008 May;67(5):423-30. doi: 10.1111/j.1365-3083.2008.02089.x. Epub 2008 Mar 17.
The complement system is a major part of the innate immunity. The first component of the classical pathway of complement activation, C1q, plays a crucial role in the clearance of immune complexes and apoptotic bodies from the organism. Autoantibodies against C1q (anti-C1q) have been found in a number of autoimmune and infectious diseases. They have been best described in patients with systemic lupus erythematosus, where they are thought to play a pathogenic role in lupus nephritis (LN). Their high negative predictive value for the occurrence of active proliferative LN, as well as their possible ability to indicate a renal flare as soon as 6 months in advance, have rendered anti-C1q antibodies a novel non-invasive tool in the detection of active LN.
补体系统是固有免疫的主要组成部分。补体激活经典途径的首个成分C1q，在清除机体中的免疫复合物和凋亡小体方面发挥着关键作用。在多种自身免疫性疾病和感染性疾病中都发现了抗C1q自身抗体（抗C1q）。它们在系统性红斑狼疮患者中得到了最充分的描述，在系统性红斑狼疮中，它们被认为在狼疮性肾炎（LN）中发挥致病作用。它们对活动性增殖性LN发生的高阴性预测价值，以及它们可能提前6个月就指示肾脏病情复发的能力，使得抗C1q抗体成为检测活动性LN的一种新型非侵入性工具。
