Stoll R, Faucounau N
Laboratoire d'Histologie-Embryologie, Faculté de Médecine Paul-Broca, Université Bordeaux II.
C R Seances Soc Biol Fil. 1991;185(4):206-10.
Treatment of female chick embryo with norethindrone (NET), a potent progesterone-like steroid, caused caudal agenesia and cephalic regression of Mullerian ducts as the normal regression induced by anti-Mullerian-hormone in the male embryo. The comparative study of five other progesterone-like steroids shows that only lynestrenol which is metabolized into NET at least in man, possesses the same properties as NET. The four others, i.e. medroxyprogesterone, medrogestone, norgestrienone and 17 alpha hydroxyprogesterone are only able to induce agenesia, an unspecific property, which was observed with many steroidal hormones, as norethandrolone here studied.
用炔诺酮（NET），一种强效的孕酮样甾体，处理雌性鸡胚，会导致尾端发育不全和苗勒管头端退化，如同雄性胚胎中抗苗勒管激素诱导的正常退化一样。对其他五种孕酮样甾体的比较研究表明，只有炔雌醇甲醚，至少在人体内会代谢为炔诺酮，具有与炔诺酮相同的特性。其他四种，即甲羟孕酮、甲地孕酮、诺孕三烯酮和17α-羟孕酮，只能诱导发育不全，这是一种非特异性特性，许多甾体激素都有此特性，比如这里研究的去甲雄酮。
