Milei J, Storino R A, Beigelman R, Fernandez Alonso G, Matturri L, Rossi L
Hospital Fernández, Buenos Aires, Argentina.
Cardiologia. 1991 Feb;36(2):107-15.
Chagas disease, in the chronic phase, is known to be characterized by cardiac failure, and/or arrhythmias. To assess the involvement of the conduction system and of the working myocardium, morphometric and immunohistochemistry studies have been carried out on 4 autoptic hearts of chronic chagasic myocardiopathy. The characterization of interstitial infiltrates was performed by lymphocyte immunophenotyping with immunocytochemical techniques. These infiltrates were more prominent in the working myocardium and in the left branch of the His bundle. The infiltrates consisted of about 50% of macrophages and 50% of T-lymphocytes. Mast cells would not play a role in the chronic stages of the disease. Eosinophils were present in no more than the 5% of the inflammation. The fibrosis, especially of the conducting system seems to be facilitated by an impaired lymphatic outflow, whereas the evidence of neuroganglionic involvement was variable.
已知恰加斯病在慢性期的特征为心力衰竭和/或心律失常。为评估传导系统和工作心肌的受累情况，对4例慢性恰加斯性心肌病的尸检心脏进行了形态计量学和免疫组织化学研究。采用免疫细胞化学技术通过淋巴细胞免疫表型分析对间质浸润进行了表征。这些浸润在工作心肌和希氏束左支中更为明显。浸润细胞约50%为巨噬细胞，50%为T淋巴细胞。肥大细胞在该疾病的慢性阶段不起作用。嗜酸性粒细胞在炎症中所占比例不超过5%。纤维化，尤其是传导系统的纤维化似乎因淋巴引流受损而加重，而神经节受累的证据则各不相同。
