齐墩果酸增强胰腺β细胞中的胰岛素分泌。
Oleanolic acid enhances insulin secretion in pancreatic beta-cells.
作者信息
Teodoro Tracy, Zhang Liling, Alexander Todd, Yue Jessica, Vranic Mladen, Volchuk Allen
机构信息
Toronto General Research Institute, University Health Network, Toronto, ON, Canada M5G1L7.
出版信息
FEBS Lett. 2008 Apr 16;582(9):1375-80. doi: 10.1016/j.febslet.2008.03.026. Epub 2008 Mar 24.
We investigated the effect of oleanolic acid, a plant-derived triterpenoid, on insulin secretion and content in pancreatic beta-cells and rat islets. Oleanolic acid significantly enhanced insulin secretion at basal and stimulatory glucose concentrations in INS-1 832/13 cells and enhanced acute glucose-stimulated insulin secretion in isolated rat islets. In the cell line the effects of oleanolic acid on insulin secretion were comparable to that of the sulfonylurea tolbutamide at basal glucose levels and with the incretin mimetic Exendin-4 under glucose-stimulated conditions, yet neither Ca(2+) nor cAMP rose in response to oleanolic acid. Chronic treatment with oleanolic acid increased total cellular insulin protein and mRNA levels. These effects may contribute to the anti-diabetic properties of this natural product.
我们研究了植物来源的三萜类化合物齐墩果酸对胰腺β细胞和大鼠胰岛中胰岛素分泌及含量的影响。齐墩果酸显著增强了INS-1 832/13细胞在基础葡萄糖浓度和刺激葡萄糖浓度下的胰岛素分泌，并增强了分离的大鼠胰岛中急性葡萄糖刺激的胰岛素分泌。在细胞系中，齐墩果酸对胰岛素分泌的影响在基础葡萄糖水平下与磺脲类药物甲苯磺丁脲相当，在葡萄糖刺激条件下与肠促胰岛素类似物艾塞那肽-4相当，但齐墩果酸刺激后Ca(2+)和cAMP均未升高。齐墩果酸的长期处理增加了细胞内胰岛素总蛋白和mRNA水平。这些作用可能有助于这种天然产物的抗糖尿病特性。
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