Araujo Andre B, Travison Thomas G, Leder Benjamin Z, McKinlay John B
New England Research Institutes, 9 Galen Street, Watertown, MA 02472, USA.
J Clin Endocrinol Metab. 2008 Jun;93(6):2135-41. doi: 10.1210/jc.2007-1469. Epub 2008 Mar 25.
The relationship between hormones and bone mineral density (BMD) in men has received considerable attention. However, most studies have been conducted in homogenous populations, and it is not known whether differences in hormones impact racial and ethnic differences in BMD.
Our objective was to examine associations of testosterone, estradiol, and sex hormone-binding globulin (SHBG) with BMD in a racially and ethnically diverse population.
This was a population-based, observational survey.
A total of 976 Black, Hispanic, and white randomly selected men ages 30-79 yr from the Boston Area Community Health/Bone Survey were included.
BMD at the hip, wrist, and spine were calculated.
The mean age of the sample was 46.7 +/- 12.4 yr. BMD levels were highest in black men, followed by Hispanic and then white men. Associations between hormones and BMD were consistent across racial and ethnic groups. Total and free testosterone was not correlated with BMD in age- or multivariate-adjusted models. SHBG was inversely correlated with total hip and ultradistal radius BMD after age adjustment, but not with multivariate adjustment for age, lean mass, fat mass, physical activity, self-rated health, and smoking. Total and free estradiol levels were positively and significantly correlated with femoral neck and total hip BMD, even with multivariate adjustment (partial correlations ranged between 0.11 and 0.16). However, estradiol levels failed to account for racial and ethnic differences in hip BMD.
In our diverse population, neither serum total nor free testosterone levels were associated with BMD. Correlations between BMD and estradiol were significant but did not appear to account for any of the observed racial and ethnic differences in BMD. These findings suggest that differences in hormone levels are not a major contributor to the observed differences in BMD between Black, Hispanic, and white men.
男性激素与骨密度（BMD）之间的关系已受到相当多的关注。然而，大多数研究是在同质人群中进行的，尚不清楚激素差异是否会影响BMD的种族和民族差异。
我们的目的是在一个种族和民族多样化的人群中研究睾酮、雌二醇和性激素结合球蛋白（SHBG）与BMD的关联。
这是一项基于人群的观察性调查。
共纳入了976名从波士顿地区社区健康/骨密度调查中随机选取的年龄在30 - 79岁之间的黑人、西班牙裔和白人男性。
计算髋部、腕部和脊柱的骨密度。
样本的平均年龄为46.7±12.4岁。黑人男性的骨密度水平最高，其次是西班牙裔男性，然后是白人男性。激素与骨密度之间的关联在不同种族和民族群体中是一致的。在年龄或多变量调整模型中，总睾酮和游离睾酮与骨密度均无相关性。年龄调整后，SHBG与全髋和桡骨远端BMD呈负相关，但在对年龄、瘦体重、脂肪量、身体活动、自我健康评分和吸烟进行多变量调整后则无相关性。总雌二醇和游离雌二醇水平与股骨颈和全髋BMD呈正且显著相关，即使进行多变量调整（偏相关系数在0.11至0.16之间）。然而，雌二醇水平未能解释髋部BMD的种族和民族差异。
在我们这个多样化的人群中，血清总睾酮和游离睾酮水平均与骨密度无关。骨密度与雌二醇之间的相关性显著，但似乎并未解释所观察到的骨密度在种族和民族上的差异。这些发现表明，激素水平差异并非黑人男性、西班牙裔男性和白人男性之间所观察到的骨密度差异的主要原因。
