Department of Orthopedics, Affiliated Zhongshan Hospital of Dalian University, Dalian, China.
Department of Cardiology, Affiliated Zhongshan Hospital of Dalian University, Dalian, China.
BMC Musculoskelet Disord. 2022 Aug 17;23(1):786. doi: 10.1186/s12891-022-05736-5.
Investigations of the relationship between waist circumference (WC) and bone mineral density (BMD) have inconsistent and incomprehensive results. We explored the association between WC and BMD at various sites in a large-scale population-based study.
We screened 5337 participants from National Health and Nutrition Examination Survey (NHANES) database. BMD was measured using dual-energy X-ray absorptiometry at various skeletal sites. The associations of WC with BMD were evaluated by weighted multivariable logistic regression models and conducted subgroup analyses for gender, age, and BMI. A weighted generalized additive model and a smooth curve fitting were performed to address non-linearity.
Adjustments for all confounders, in males, WC was negatively correlated to BMD in different age and BMI groups (all the p < 0.05), except for in the lowest BMI group; in females, overall trends of relationships between WC and BMD were negative. However, statistical differences were insignificant in some cases. Additionally, every 1 cm increase in WC for individuals of all ages with normal BMI (18.5 ≤ BMI < 25) was associated with decrease in BMD at each skeletal site, as was the case for men with BMI ≥ 25 kg/m. For women, the negative association of WC with BMD was evident at the lumbar spine in the youngest age group (8 ≤ Age ≤ 18) with normal BMI.
The nonlinear associations between WC and BMD at various skeletal sites are gender-, age- and BMI-specific in the NHANES (2006-2006).
腰围（WC）与骨密度（BMD）之间关系的研究结果不一致且不全面。我们在一项大规模的基于人群的研究中探讨了 WC 与各部位 BMD 之间的相关性。
我们从国家健康和营养检查调查（NHANES）数据库中筛选了 5337 名参与者。使用双能 X 射线吸收法在各种骨骼部位测量 BMD。通过加权多变量逻辑回归模型评估 WC 与 BMD 的相关性，并针对性别、年龄和 BMI 进行了亚组分析。使用加权广义加性模型和平滑曲线拟合来解决非线性问题。
在男性中，调整所有混杂因素后，WC 与不同年龄和 BMI 组的 BMD 呈负相关（均 P<0.05），除了 BMI 最低组外；在女性中，WC 与 BMD 之间的关系总体呈负相关。然而，在某些情况下，统计学差异不显著。此外，对于所有年龄且 BMI 正常（18.5≤BMI<25）的个体，每增加 1 厘米 WC 与各骨骼部位的 BMD 降低相关，对于 BMI≥25kg/m 的男性也是如此。对于女性，在 BMI 正常的最年轻年龄组（8≤年龄≤18），WC 与 BMD 的负相关在腰椎处更为明显。
NHANES（2006-2006）中，WC 与各骨骼部位 BMD 之间的非线性关系具有性别、年龄和 BMI 特异性。
