Du Huini, Yang Yongfeng, Cherry Simon R
Department of Biomedical Engineering, University of California-Davis, One Shields Avenue, CA 95616, USA.
Phys Med Biol. 2008 Apr 7;53(7):1829-42. doi: 10.1088/0031-9155/53/7/002. Epub 2008 Mar 10.
We propose detectors for a laboratory positron emission tomography scanner specific for mouse imaging that utilizes fewer detectors and channels of electronics compared with existing designs. The detectors are based on lutetium oxyorthosilicate arrays, read out by orthogonal optical fibers placed on the top and bottom of the arrays. Depth of interaction (DOI) information is obtained from the ratio of the signals at either end of the array. Four different detector modules were evaluated, using different reflector materials and two types of optical fibers (wavelength shifting (WLS) fibers and clear optical fibers). The modules were compared in terms of flood histograms, energy resolution, DOI resolution and timing resolution. Energy resolution for single crystals at one irradiation depth was around 65% full-width half-maximum (FWHM). A DOI resolution of approximately 6 mm was obtained for the modules. Timing resolution was in the range of 5.1-7.8 ns. An array assembled in the laboratory and coupled with WLS fibers had the best DOI resolution; the same array with clear fibers had the best timing resolution and a commercially manufactured array and coupled with WLS fibers had the best energy resolution.
我们提出了一种用于实验室正电子发射断层扫描扫描仪的探测器，该扫描仪专门用于小鼠成像，与现有设计相比，它使用的探测器和电子通道更少。探测器基于正硅酸镥阵列，通过放置在阵列顶部和底部的正交光纤进行读出。相互作用深度（DOI）信息从阵列两端信号的比值中获得。评估了四种不同的探测器模块，使用了不同的反射器材料和两种类型的光纤（波长转移（WLS）光纤和透明光纤）。从泛光直方图、能量分辨率、DOI分辨率和时间分辨率方面对这些模块进行了比较。在一个照射深度下，单晶的能量分辨率约为半高宽（FWHM）的65%。这些模块获得了约6毫米的DOI分辨率。时间分辨率在5.1 - 7.8纳秒范围内。在实验室组装并与WLS光纤耦合的阵列具有最佳的DOI分辨率；使用透明光纤的相同阵列具有最佳的时间分辨率，而商业制造的阵列与WLS光纤耦合具有最佳的能量分辨率。
