• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

使用涂有磷光体的闪烁体进行连续相互作用深度编码。

Continuous depth-of-interaction encoding using phosphor-coated scintillators.

作者信息

Du Huini, Yang Yongfeng, Glodo Jarek, Wu Yibao, Shah Kanai, Cherry Simon R

机构信息

Department of Biomedical Engineering, University of California-Davis, One Shields Avenue, Davis, CA 95616, USA.

出版信息

Phys Med Biol. 2009 Mar 21;54(6):1757-71. doi: 10.1088/0031-9155/54/6/023. Epub 2009 Mar 3.

DOI:10.1088/0031-9155/54/6/023
PMID:19258685
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2748919/
Abstract

We investigate a novel detector using a lutetium oxyorthosilicate (LSO) scintillator and YGG (yttrium-aluminum-gallium oxide:cerium, Y(3)(Al,Ga)(5)O(12):Ce) phosphor to construct a detector with continuous depth-of-interaction (DOI) information. The far end of the LSO scintillator is coated with a thin layer of YGG phosphor powder which absorbs some fraction of the LSO scintillation light and emits wavelength-shifted photons with a characteristic decay time of approximately 50 ns. The near end of the LSO scintillator is directly coupled to a photodetector. The photodetector detects a mixture of the LSO light and the light emitted by YGG. With appropriate placement of the coating, the ratio of the light converted from the YGG coating with respect to the unconverted LSO light can be made to depend on the interaction depth. DOI information can then be estimated by inspecting the overall light pulse decay time. Experiments were conducted to optimize the coating method. 19 ns decay time differences across the length of the detector were achieved experimentally when reading out a 1.5 x 1.5 x 20 mm(3) LSO crystal with unpolished surfaces and half-coated with YGG phosphor. The same coating scheme was applied to a 4 x 4 LSO array. Pulse shape discrimination (PSD) methods were studied to extract DOI information from the pulse shape changes. The DOI full-width-half-maximum (FWHM) resolution was found to be approximately 8 mm for this 2 cm thick array.

摘要

我们研究了一种新型探测器,它使用正硅酸镥(LSO)闪烁体和钇铝镓氧化物(YGG:铈,Y(3)(Al,Ga)(5)O(12):Ce)磷光体来构建一个具有连续相互作用深度(DOI)信息的探测器。LSO闪烁体的远端涂有一层薄薄的YGG磷光体粉末,该粉末吸收一部分LSO闪烁光,并发射具有约50 ns特征衰减时间的波长移位光子。LSO闪烁体的近端直接与光电探测器耦合。光电探测器检测LSO光和YGG发射的光的混合光。通过适当放置涂层,可以使从YGG涂层转换的光相对于未转换的LSO光的比例取决于相互作用深度。然后可以通过检查整体光脉冲衰减时间来估计DOI信息。进行了实验以优化涂层方法。当读出一个1.5×1.5×20 mm(3)、表面未抛光且一半涂有YGG磷光体的LSO晶体时,通过实验实现了探测器长度上19 ns的衰减时间差异。相同的涂层方案应用于一个4×4的LSO阵列。研究了脉冲形状甄别(PSD)方法,以从脉冲形状变化中提取DOI信息。对于这个2厘米厚的阵列,发现DOI半高宽(FWHM)分辨率约为8毫米。

相似文献

1
Continuous depth-of-interaction encoding using phosphor-coated scintillators.使用涂有磷光体的闪烁体进行连续相互作用深度编码。
Phys Med Biol. 2009 Mar 21;54(6):1757-71. doi: 10.1088/0031-9155/54/6/023. Epub 2009 Mar 3.
2
Timing properties of phosphor-coated polished LSO crystals.涂有磷光体的抛光LSO晶体的计时特性。
Phys Med Biol. 2014 Aug 7;59(15):N139-51. doi: 10.1088/0031-9155/59/15/N139. Epub 2014 Jul 22.
3
Monte Carlo calculations of PET coincidence timing: single and double-ended readout.正电子发射断层扫描(PET)符合时间的蒙特卡罗计算:单端和双端读出
Phys Med Biol. 2015 Sep 21;60(18):7309-38. doi: 10.1088/0031-9155/60/18/7309. Epub 2015 Sep 9.
4
Monte Carlo study on the imaging performance of powder Lu2SiO5:Ce phosphor screens under x-ray excitation: comparison with Gd2O2S:Tb screens.X射线激发下粉末状Lu2SiO5:Ce磷光屏成像性能的蒙特卡罗研究:与Gd2O2S:Tb屏的比较
Med Phys. 2007 May;34(5):1724-33. doi: 10.1118/1.2724065.
5
Measurement of intrinsic rise times for various L(Y)SO and LuAG scintillators with a general study of prompt photons to achieve 10 ps in TOF-PET.测量各种L(Y)SO和LuAG闪烁体的本征上升时间,并对瞬发光子进行全面研究,以在飞行时间正电子发射断层扫描(TOF-PET)中实现10皮秒的时间分辨率。
Phys Med Biol. 2016 Apr 7;61(7):2802-37. doi: 10.1088/0031-9155/61/7/2802. Epub 2016 Mar 16.
6
Monte Carlo simulations of time-of-flight PET with double-ended readout: calibration, coincidence resolving times and statistical lower bounds.具有双端读出的飞行时间正电子发射断层扫描的蒙特卡罗模拟:校准、符合分辨时间和统计下限。
Phys Med Biol. 2017 May 7;62(9):3828-3858. doi: 10.1088/1361-6560/aa6862. Epub 2017 Mar 22.
7
A thick semi-monolithic scintillator detector for clinical PET scanners.一种用于临床 PET 扫描仪的厚半整体闪烁体探测器。
Phys Med Biol. 2021 Mar 12;66(6):065023. doi: 10.1088/1361-6560/abe761.
8
Predicting the timing properties of phosphor-coated scintillators using Monte Carlo light transport simulation.使用蒙特卡罗光传输模拟预测磷光体涂层闪烁体的时间特性。
Phys Med Biol. 2014 Apr 21;59(8):2023-39. doi: 10.1088/0031-9155/59/8/2023. Epub 2014 Apr 2.
9
A novel phoswich imaging detector for simultaneous beta and coincidence-gamma imaging of plant leaves.一种新型的磷光体符合成像探测器,用于植物叶片的β射线和符合γ射线同时成像。
Phys Med Biol. 2011 Sep 7;56(17):5583-98. doi: 10.1088/0031-9155/56/17/008. Epub 2011 Aug 9.
10
A sub-millimeter resolution PET detector module using a multi-pixel photon counter array.一种使用多像素光子计数器阵列的亚毫米分辨率 PET 探测器模块。
Phys Med Biol. 2010 May 7;55(9):2573-87. doi: 10.1088/0031-9155/55/9/010. Epub 2010 Apr 14.

引用本文的文献

1
A time-based single transmission-line readout with position multiplexing.一种基于时间的具有位置复用功能的单传输线读出方式。
Biomed Eng Lett. 2022 Jan 17;12(1):85-95. doi: 10.1007/s13534-022-00215-1. eCollection 2022 Feb.
2
A digital phoswich detector using time-over-threshold for depth of interaction in PET.一种使用时间超越阈值的数字磷光体探测器,用于 PET 中的相互作用深度。
Phys Med Biol. 2020 Dec 15;65(24):245017. doi: 10.1088/1361-6560/abcb21.
3
Prismatoid light guide array for enhanced gamma ray localization in PET: a Monte Carlo simulation study of scintillation photon transport.

本文引用的文献

1
A prototype PET scanner with DOI-encoding detectors.一种带有深度编码探测器的正电子发射断层扫描(PET)扫描仪原型。
J Nucl Med. 2008 Jul;49(7):1132-40. doi: 10.2967/jnumed.107.049791. Epub 2008 Jun 13.
2
Comparison of four depth-encoding PET detector modules with wavelength shifting (WLS) and optical fiber read-out.四种采用波长转换(WLS)和光纤读出的深度编码PET探测器模块的比较。
Phys Med Biol. 2008 Apr 7;53(7):1829-42. doi: 10.1088/0031-9155/53/7/002. Epub 2008 Mar 10.
3
Measurements of wavelength shifting (WLS) fibre readout for a highly multiplexed, depth-encoding PET detector.
用于增强正电子发射断层成像中伽马射线定位的棱镜状光导阵列:闪烁光子输运的蒙特卡罗模拟研究。
Phys Med Biol. 2020 Sep 16;65(18):18LT01. doi: 10.1088/1361-6560/ab9373.
4
Feasibility of Using Crystal Geometry for a DOI Scintillation Detector.将晶体几何结构用于DOI闪烁探测器的可行性。
IEEE Trans Radiat Plasma Med Sci. 2018 May;2(3):161-169. doi: 10.1109/TRPMS.2018.2760857. Epub 2017 Oct 6.
5
A depth-of-interaction encoding PET detector module with dual-ended readout using large-area silicon photomultiplier arrays.一种使用大面积硅光电倍增管阵列的具有双端读出的深度交互编码 PET 探测器模块。
Phys Med Biol. 2018 Dec 14;63(24):245019. doi: 10.1088/1361-6560/aaee32.
6
Innovations in Instrumentation for Positron Emission Tomography.正电子发射断层成像仪的创新。
Semin Nucl Med. 2018 Jul;48(4):311-331. doi: 10.1053/j.semnuclmed.2018.02.006. Epub 2018 Mar 12.
7
Reaching 200-ps timing resolution in a time-of-flight and depth-of-interaction positron emission tomography detector using phosphor-coated crystals and high-density silicon photomultipliers.在使用涂有磷光体的晶体和高密度硅光电倍增管的飞行时间和相互作用深度正电子发射断层扫描探测器中实现200皮秒的时间分辨率。
J Med Imaging (Bellingham). 2016 Oct;3(4):043501. doi: 10.1117/1.JMI.3.4.043501. Epub 2016 Nov 23.
8
Improving Depth, Energy and Timing Estimation in PET Detectors with Deconvolution and Maximum Likelihood Pulse Shape Discrimination.利用反卷积和最大似然脉冲形状鉴别改善正电子发射断层显像(PET)探测器中的深度、能量和时间估计
IEEE Trans Med Imaging. 2016 Nov;35(11):2436-2446. doi: 10.1109/TMI.2016.2577539. Epub 2016 Jun 7.
9
A combined time-of-flight and depth-of-interaction detector for total-body positron emission tomography.一种用于全身正电子发射断层扫描的飞行时间与相互作用深度组合探测器。
Med Phys. 2016 Feb;43(2):939-50. doi: 10.1118/1.4940355.
10
A DOI Detector With Crystal Scatter Identification Capability for High Sensitivity and High Spatial Resolution PET Imaging.一种具有晶体散射识别能力的DOI探测器,用于高灵敏度和高空间分辨率PET成像。
IEEE Trans Nucl Sci. 2015 Jun;62(3):740-747. doi: 10.1109/TNS.2015.2408333.
用于高度复用、深度编码正电子发射断层扫描(PET)探测器的波长转移(WLS)光纤读出测量。
Phys Med Biol. 2007 May 7;52(9):2499-514. doi: 10.1088/0031-9155/52/9/011. Epub 2007 Apr 10.
4
Performance evaluation of the GE healthcare eXplore VISTA dual-ring small-animal PET scanner.通用电气医疗集团eXplore VISTA双环小动物正电子发射断层扫描仪的性能评估
J Nucl Med. 2006 Nov;47(11):1891-900.
5
Depth of interaction resolution measurements for a high resolution PET detector using position sensitive avalanche photodiodes.使用位置敏感雪崩光电二极管的高分辨率正电子发射断层显像(PET)探测器的相互作用深度分辨率测量
Phys Med Biol. 2006 May 7;51(9):2131-42. doi: 10.1088/0031-9155/51/9/001. Epub 2006 Apr 10.
6
Evaluation of high performance data acquisition boards for simultaneous sampling of fast signals from PET detectors.用于同时采集来自正电子发射断层扫描(PET)探测器的快速信号的高性能数据采集板的评估。
Phys Med Biol. 2005 Jan 7;50(1):29-44. doi: 10.1088/0031-9155/50/1/003.