Zhang Qizhi, Liu Zhao, Carney Paul R, Yuan Zhen, Chen Huanxin, Roper Steven N, Jiang Huabei
The J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL 32611, USA.
Phys Med Biol. 2008 Apr 7;53(7):1921-31. doi: 10.1088/0031-9155/53/7/008. Epub 2008 Mar 11.
Non-invasive laser-induced photoacoustic tomography (PAT) is an emerging imaging modality that has the potential to image the dynamic function of the brain due to its unique ability of imaging biological tissues with high optical contrast and ultrasound resolution. Here we report the first application of our finite-element-based PAT for imaging of epileptic seizures in an animal model. In vivo photoacoustic images were obtained in rats with focal seizures induced by microinjection of bicuculline, a GABA(A) antagonist, into the neocortex. The seizure focus was accurately localized by PAT as confirmed with gold-standard electroencephalogram (EEG). Compared to the existing neuroimaging modalities, PAT not only has the unprecedented advantage of high spatial and temporal resolution in a single imaging modality, but also is portable and low in cost, making it possible to bring brain imaging to the bedside.
无创激光诱导光声断层扫描（PAT）是一种新兴的成像方式，因其具有以高光学对比度和超声分辨率对生物组织进行成像的独特能力，所以有潜力对大脑的动态功能进行成像。在此，我们报告了基于有限元的PAT在动物模型癫痫发作成像中的首次应用。通过向新皮层微量注射γ-氨基丁酸A（GABA(A)）拮抗剂荷包牡丹碱诱导局灶性癫痫发作的大鼠体内获得了光声图像。如金标准脑电图（EEG）所证实，癫痫病灶通过PAT被准确地定位。与现有的神经成像方式相比，PAT不仅在单一成像方式中具有前所未有的高空间和时间分辨率优势，而且便于携带且成本低廉，使得床边脑成像成为可能。
