基于辐射传输的频域荧光断层扫描。
Radiative transport-based frequency-domain fluorescence tomography.
作者信息
Joshi Amit, Rasmussen John C, Sevick-Muraca Eva M, Wareing Todd A, McGhee John
机构信息
Division of Molecular Imaging, Department of Radiology, Baylor College of Medicine, Houston, TX 77030, USA.
出版信息
Phys Med Biol. 2008 Apr 21;53(8):2069-88. doi: 10.1088/0031-9155/53/8/005. Epub 2008 Mar 26.
Abstract
We report the development of radiative transport model-based fluorescence optical tomography from frequency-domain boundary measurements. The coupled radiative transport model for describing NIR fluorescence propagation in tissue is solved by a novel software based on the established Attila particle transport simulation platform. The proposed scheme enables the prediction of fluorescence measurements with non-contact sources and detectors at a minimal computational cost. An adjoint transport solution-based fluorescence tomography algorithm is implemented on dual grids to efficiently assemble the measurement sensitivity Jacobian matrix. Finally, we demonstrate fluorescence tomography on a realistic computational mouse model to locate nM to microM fluorophore concentration distributions in simulated mouse organs.
摘要
我们报告了基于频域边界测量的辐射传输模型荧光光学断层成像技术的进展。通过基于已建立的阿提拉粒子传输模拟平台的新型软件，求解了用于描述近红外荧光在组织中传播的耦合辐射传输模型。所提出的方案能够以最小的计算成本，利用非接触式源和探测器预测荧光测量结果。基于伴随传输解的荧光断层成像算法在双网格上实现，以有效地组装测量灵敏度雅可比矩阵。最后，我们在逼真的计算小鼠模型上展示了荧光断层成像，以定位模拟小鼠器官中纳摩尔至微摩尔荧光团浓度分布。
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