Yang Jinbo, Stark George R
School of Biological Science, Lanzhou University, Lanzhou, Gansu 730000, China.
Cell Res. 2008 Apr;18(4):443-51. doi: 10.1038/cr.2008.41.
The seven members of the signal transducer and activator of transcription (STAT) family of transcription factors are activated in response to many different cytokines and growth factors by phosphorylation of specific tyrosine residues. The STAT1 and STAT3 genes are specific targets of activated STATs 1 and 3, respectively, resulting in large increases in the levels of these unphosphorylated STATs (U-STATs) in response to the interferons (STAT1) or ligands that active gp130, such as IL-6 (STAT3). U-STATs drive gene expression by novel mechanisms distinct from those used by phosphorylated STAT (P-STAT) dimers. In this review, we discuss the roles of U-STATs in transcription and regulation of gene expression.
信号转导及转录激活因子（STAT）家族的七个成员作为转录因子，通过特定酪氨酸残基的磷酸化，对多种不同的细胞因子和生长因子作出反应而被激活。STAT1和STAT3基因分别是活化的STAT1和STAT3的特异性靶点，导致在受到干扰素（针对STAT1）或激活gp130的配体（如IL-6，针对STAT3）刺激时，这些未磷酸化的STAT（U-STAT）水平大幅增加。U-STAT通过不同于磷酸化STAT（P-STAT）二聚体的新机制驱动基因表达。在本综述中，我们讨论了U-STAT在转录和基因表达调控中的作用。
