[来自远东海星多棘海盘车的多羟基甾体化合物]

[Polyhydroxylated steroid compounds from the Far Eastern starfish Distolasterias nipon].

作者信息

Kicha A A, Kapustina I I, Ivanchina N V, Kalinovskiííí A I, Dmitrenok I S, Stonik V A, Pal'ianova N V, Pankova T M, Starostina M V

出版信息

Bioorg Khim. 2008 Jan-Feb;34(1):129-35. doi: 10.1134/s1068162008010160.

DOI:10.1134/s1068162008010160

PMID:18365748

Abstract

Two new steroid glycosides: distolasteroside D6, (24S)-24-O-(beta-D-xylopyranosyl)-5alpha-cholestane-3beta,6alpha,8,15beta,16beta,24-hexaol, and distolasteroside D7. (22E,24R)-24-O-(beta-D-xylopyranosyl)-5alpha-cholest-22-ene-3beta,6alpha,8,15beta,24-pentaol were isolated along with the previously known distolasterosides D1, D2, and D3, echinasteroside C, and (25S)-5alpha-cholestane-3beta,4beta,6alpha,7alpha,8,15alpha,16beta,26-octaol from the Far Eastern starfish Distolasterias nipon. The structures of new compounds were elucidated by NMR spectroscopy and MALDI TOF mass spectrometry. Like neurotrophins, distolasterosides D1, D2, and D3 were shown to induce neuroblast differentiation in a mouse neuroblastoma C 1300 cell culture.

摘要

两种新的甾体糖苷

双托拉甾苷D6，(24S)-24-O-(β-D-吡喃木糖基)-5α-胆甾烷-3β,6α,8,15β,16β,24-六醇，以及双托拉甾苷D7，(22E,24R)-24-O-(β-D-吡喃木糖基)-5α-胆甾-22-烯-3β,6α,8,15β,24-五醇，与先前已知的双托拉甾苷D1、D2和D3、海盘车苷C以及(25S)-5α-胆甾烷-3β,4β,6α,7α,8,15α,16β,26-八醇一起，从远东海星日本双托拉海星中分离得到。通过核磁共振光谱和基质辅助激光解吸电离飞行时间质谱对新化合物的结构进行了阐明。与神经营养因子一样，双托拉甾苷D1、D2和D3在小鼠神经母细胞瘤C 1300细胞培养中显示出诱导神经母细胞分化的作用。