Institute of Life Sciences and Biomedicine, Far Eastern Federal University, 8 ul. Sukhanova, 690950 Vladivostok, Russia.
A.V. Zhirmunsky National Center of Marine Biology, Far Eastern Branch, Russian Academy of Sciences, 690950 Vladivostok, Russia.
Mar Drugs. 2022 Nov 11;20(11):708. doi: 10.3390/md20110708.
Neurodegenerative diseases are growing to become one of humanity's biggest health problems, given the number of individuals affected by them. They cause enough mortalities and severe economic impact to rival cancers and infections. With the current diversity of pathophysiological mechanisms involved in neurodegenerative diseases, on the one hand, and scarcity of efficient prevention and treatment strategies, on the other, all possible sources for novel drug discovery must be employed. Marine pharmacology represents a relatively uncharted territory to seek promising compounds, despite the enormous chemodiversity it offers. The current work discusses one vast marine region-the Northwestern or Russian Pacific-as the treasure chest for marine-based drug discovery targeting neurodegenerative diseases. We overview the natural products of neurological properties already discovered from its waters and survey the existing molecular and cellular targets for pharmacological modulation of the disease. We further provide a general assessment of the drug discovery potential of the Russian Pacific in case of its systematic development to tackle neurodegenerative diseases.
神经退行性疾病正在成为人类最大的健康问题之一，考虑到受其影响的人数。它们造成的死亡率和严重的经济影响足以与癌症和感染相媲美。鉴于神经退行性疾病所涉及的病理生理机制的多样性，一方面，以及缺乏有效的预防和治疗策略，另一方面，必须利用所有可能的新药物发现来源。尽管海洋药理学提供了巨大的化学多样性，但它仍然是一个相对未知的领域，可以寻找有前途的化合物。目前的工作讨论了一个广阔的海洋区域——西北太平洋或俄罗斯太平洋——作为针对神经退行性疾病的基于海洋的药物发现的宝库。我们综述了已经从其水域中发现的具有神经特性的天然产物，并调查了用于调节疾病的分子和细胞靶标。我们进一步提供了对俄罗斯太平洋药物发现潜力的总体评估，以防其系统开发用于治疗神经退行性疾病。
