多糖羟基甾体衍生物来自海星。

Polyhydroxylated steroid derivatives from the starfish .

机构信息

Institute of Marine Biochemistry, Vietnam Academy of Science and Technology, Hanoi, Vietnam.

Graduate University of Science and Technology, Vietnam Academy of Science and Technology, Hanoi, Vietnam.

出版信息

Nat Prod Res. 2022 May;36(9):2223-2229. doi: 10.1080/14786419.2020.1826478. Epub 2020 Sep 30.

DOI:10.1080/14786419.2020.1826478

PMID:32993368

Abstract

A new polyhydroxysteroid glycoside, regulusoside D (), and a new polyhydroxylated steroid, (24)-cholestane-3,5,6,8,15,24-hexol (), together with seven known compounds were purified from the starfish collected near Con Co Islands, Vietnam. The structure elucidation was confirmed by extensive analysis of their NMR and HR-QTOF mass experiments. Among isolated compounds, regulusoside D (), (24)-cholestane-3,5,6,8,15,24-hexol (), granulatoside A (), 5-cholestane-3,6,7α,15,16,26-hexol (), 5-cholestane-3,6,7,8,15,16,26-heptol () and 5-cholestane-3,6,8,15,16,26-hexol () exhibited strong inhibitory effects on LPS-induced NO production in RAW264.7 cells with IC values of 9.13 ± 1.17, 9.19 ± 0.77, 8.63 ± 3.31, 12.61 ± 0.51, 14.83 ± 3.02 and 10.98 ± 1.22 µM, respectively.

摘要

从越南附近的 Con Co 群岛采集的海星中分离得到一种新的多羟基甾醇糖苷 regulusoside D () 和一种新的多羟基甾醇 (24)-胆甾烷-3,5,6,8,15,24-六醇 ()，以及 7 种已知化合物。通过对其 NMR 和 HR-QTOF 质谱实验的广泛分析，确定了其结构。在所分离的化合物中，regulusoside D ()、(24)-胆甾烷-3,5,6,8,15,24-六醇 ()、granulatoside A ()、5-胆甾烷-3,6,7α,15,16,26-六醇 ()、5-胆甾烷-3,6,7,8,15,16,26-庚醇 () 和 5-胆甾烷-3,6,8,15,16,26-六醇 () 对 LPS 诱导的 RAW264.7 细胞中 NO 生成具有较强的抑制作用，IC 值分别为 9.13±1.17、9.19±0.77、8.63±3.31、12.61±0.51、14.83±3.02 和 10.98±1.22 μM。