Vincent Adele J, Lau Patricia W, Roskams A Jane
Department of Zoology, University of British Columbia, Vancouver, Canada.
Dev Dyn. 2008 May;237(5):1449-62. doi: 10.1002/dvdy.21495.
SPARC (secreted protein, acidic and rich in cysteine) is a matricellular protein that is highly expressed during development, tissue remodeling, and repair. SPARC produced by olfactory ensheathing cells (OECs) can promote axon sprouting in vitro and in vivo. Here, we show that in the developing nervous system of the mouse, SPARC is expressed by radial glia, blood vessels, and other pial-derived structures during embryogenesis and postnatal development. The rostral migratory stream contains SPARC that becomes progressively restricted to the SVZ in adulthood. In the adult CNS, SPARC is enriched in specialized radial glial derivatives (Müller and Bergmann glia), microglia, and brainstem astrocytes. The peripheral glia, Schwann cells, and OECs express SPARC throughout development and in maturity, although it appears to be down-regulated with maturation. These data suggest that SPARC may be expressed by glia in a spatiotemporal manner consistent with a role in cell migration, neurogenesis, synaptic plasticity, and angiogenesis.
富含半胱氨酸的酸性分泌蛋白（SPARC）是一种基质细胞蛋白，在发育、组织重塑和修复过程中高度表达。嗅鞘细胞（OECs）产生的SPARC可在体外和体内促进轴突萌发。在此，我们表明，在小鼠发育中的神经系统中，SPARC在胚胎发生和出生后发育期间由放射状胶质细胞、血管和其他软脑膜衍生结构表达。头端迁移流含有SPARC，在成年期逐渐局限于室管膜下区。在成体中枢神经系统中，SPARC在特殊的放射状胶质细胞衍生物（穆勒胶质细胞和伯格曼胶质细胞）、小胶质细胞和脑干星形胶质细胞中富集。外周胶质细胞、施万细胞和嗅鞘细胞在整个发育过程和成熟阶段都表达SPARC，尽管它似乎随着成熟而被下调。这些数据表明，SPARC可能由胶质细胞以时空方式表达，这与其在细胞迁移、神经发生、突触可塑性和血管生成中的作用一致。
