Zhao Yue, Fang Jiyu
Advanced Materials Processing and Analysis Center and Department of Mechanical, Materials, and Aerospace Engineering, University of Central Florida, Orlando, Florida 32816, USA.
Langmuir. 2008 May 6;24(9):5113-7. doi: 10.1021/la703634t. Epub 2008 Mar 27.
Lipid tubules formed by rolled-up bilayer sheets have shown promise in drug delivery systems, nanofluidics, and microelectronics. Here we report a method for directly printing lipid tubules on substrates. Preformed lipid tubules of 1,2-bis(tricosa-10,12-diynoyl)-sn-glycero-3-phosphocholine are aligned in the recessed channels of a thin poly(dimethylsiloxane) (PDMS) stamp. The aligned lipid tubules then serve as an "ink" for microcontact printing. We demonstrate that two-dimensional (2-D) arrays of aligned lipid tubules can be transferred onto planar, patterned, and curved substrates from the recessed channels of the PDMS stamp by bringing the tubule-inked PDMS stamp into contact with these substrates. We show that the 2-D array of aligned lipid tubules can be transcribed into a 2-D array of aligned silica cylinders through templated sol-gel condensation of tetraethoxysilane.
由卷起的双层片形成的脂质微管在药物递送系统、纳米流体学和微电子学方面展现出了应用前景。在此，我们报告一种在基底上直接打印脂质微管的方法。预先形成的1,2-双（二十三碳-10,12-二炔酰基）-sn-甘油-3-磷酸胆碱脂质微管排列在薄聚二甲基硅氧烷（PDMS）印章的凹槽通道中。排列好的脂质微管随后用作微接触印刷的“墨水”。我们证明，通过使带有脂质微管墨水的PDMS印章与这些基底接触，排列的脂质微管二维（2-D）阵列可以从PDMS印章的凹槽通道转移到平面、图案化和弯曲的基底上。我们表明，排列的脂质微管二维阵列可以通过四乙氧基硅烷的模板溶胶-凝胶缩合转录成排列的二氧化硅圆柱体二维阵列。
