Rogers Lisa R
Department of Neurology, University of Michigan Health System, 1920F Taubman Center, Ann Arbor, MI 48109, USA.
Curr Oncol Rep. 2008 Jan;10(1):72-7. doi: 10.1007/s11912-008-0011-1.
Cerebrovascular disorders, including brain infarction, brain hemorrhage, and cerebral venous thrombosis, can occur as an early sign of cancer, but typically occur late in the clinical course. These disorders are due to a variety of pathogenic mechanisms, including coagulation disorders associated with the cancer, invasion or compression of vessels from tumor in or adjacent to the brain, and the adverse effects of cancer therapy. The appropriate therapy for these cerebrovascular disorders is empiric in most instances, because as yet there are no prospective treatment trials for them. A review of the existing literature reveals that improvement in patient quality of life and prevention of further cerebrovascular events can be obtained in some clinical situations.
脑血管疾病，包括脑梗死、脑出血和脑静脉血栓形成，可能作为癌症的早期迹象出现，但通常在临床病程的后期发生。这些疾病是由多种致病机制引起的，包括与癌症相关的凝血障碍、肿瘤对脑内或脑附近血管的侵袭或压迫，以及癌症治疗的不良反应。在大多数情况下，针对这些脑血管疾病的适当治疗是经验性的，因为目前尚无针对它们的前瞻性治疗试验。对现有文献的回顾表明，在某些临床情况下可以提高患者的生活质量并预防进一步的脑血管事件。
