Division of Cerebrovascular Diseases, Department of Neurology, Carver College of Medicine, University of Iowa Hospitals and Clinics, University of Iowa, 200 Hawkins Drive, Iowa City, IA, 52242, USA.
Curr Neurol Neurosci Rep. 2019 Aug 23;19(10):73. doi: 10.1007/s11910-019-0985-0.
To review the latest information about the interactions between cancer and cerebrovascular disease.
Additional data support the finding that both ischemic and hemorrhagic stroke are important complications of cancer or its treatment. Reperfusion therapy is being given successfully to patients with stroke complicating cancer. Hemorrhagic stroke may occur with metastatic disease to the brain, coagulopathies from cancer, in particular leukemia, or as complications of chemotherapy. Ischemic stroke also may be a complication of metastatic disease with local invasion of vessels, a pro-thrombotic disorder such as non-bacterial thrombotic endocarditis (NBTE) or disseminated intravascular coagulation (DIC), or secondary to chemotherapy. Stroke also is a potential consequence of radiation therapy to the head and neck. Venous sinus thrombosis may develop with hematologic malignancies or chemotherapy. Although many patients will have a history of cancer at the time of stroke, a cerebrovascular event may be the initial manifestation of a malignancy.
回顾癌症与脑血管病相互作用的最新信息。
更多的数据支持这样一种发现，即缺血性卒中和出血性卒中都是癌症或其治疗的重要并发症。再灌注治疗正成功地应用于伴有癌症合并卒中的患者。转移性脑疾病、癌症引起的凝血障碍（特别是白血病）或化疗的并发症可导致出血性卒中。局部侵犯血管、非细菌性血栓性心内膜炎（NBTE）或弥散性血管内凝血（DIC）等促血栓形成性疾病，或继发于化疗的缺血性卒中也可能是并发症。卒中也是头颈部放射治疗的潜在后果。血液系统恶性肿瘤或化疗可导致静脉窦血栓形成。尽管许多患者在发生卒中时已有癌症病史，但脑血管事件可能是恶性肿瘤的首发表现。
