QT间期时长：基于人群的老年男性前瞻性研究中的决定因素及预后意义
Length of the QT interval: determinants and prognostic implications in a population-based prospective study of older men.
作者信息
Sohaib Syed Mohammad Afzal, Papacosta Olia, Morris Richard W, Macfarlane Peter W, Whincup Peter H
机构信息
Department of Primary Care and Population Sciences, Royal Free and University College Medical School, London, United Kingdom.
出版信息
J Electrocardiol. 2008 Nov-Dec;41(6):704-10. doi: 10.1016/j.jelectrocard.2008.01.010. Epub 2008 Mar 25.
OBJECTIVE
We examined potential determinants and prognostic value of the corrected QT interval (QTc).
DESIGN
A total of 4252 British men aged 60 to 79 years had a resting 12-lead electrocardiogram. Potential determinants of the QTc were assessed using multivariable regression. Men were followed up for 7 years.
RESULTS
A 1 standard deviation increase in QTc (26 milliseconds) was associated with increased all-cause mortality (hazard ratio, 1.13; 95% confidence interval, 1.05-1.22). Longer QTc was associated with increasing age, preexisting coronary heart disease, and a range of drugs. Shorter QTc was present in diabetics and smokers. Corrected QT interval was related inversely with serum potassium and calcium and positively with serum urate, sodium, and systolic blood pressure. The relation of QTc to all-cause mortality was independent of adjustment for these factors.
CONCLUSIONS
Age, preexisting coronary heart disease, certain medications and biochemical factors, and diabetes are independently associated with QTc. Corrected QT interval is an independent predictor of all-cause mortality.
目的
我们研究了校正QT间期（QTc）的潜在决定因素和预后价值。
设计
共有4252名年龄在60至79岁的英国男性进行了静息12导联心电图检查。使用多变量回归评估QTc的潜在决定因素。对男性进行了7年的随访。
结果
QTc增加1个标准差（26毫秒）与全因死亡率增加相关（风险比，1.13；95%置信区间，1.05 - 1.22）。较长的QTc与年龄增长、既往冠心病以及一系列药物有关。糖尿病患者和吸烟者的QTc较短。校正QT间期与血清钾和钙呈负相关，与血清尿酸、钠和收缩压呈正相关。QTc与全因死亡率的关系独立于对这些因素的调整。
结论
年龄、既往冠心病、某些药物和生化因素以及糖尿病与QTc独立相关。校正QT间期是全因死亡率的独立预测因素。
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