Karimi M, Rasekhi A R, Rasekh M, Nabavizadeh S A, Assadsangabi R, Amirhakimi G H
Iran-Shiraz-Namazee Hospital, Namazee Square, Hematology Research Center, Department of Pediatrics, Shiraz University of Medical Sciences, Shiraz, Iran.
Eur J Radiol. 2009 Jun;70(3):481-4. doi: 10.1016/j.ejrad.2008.02.003. Epub 2008 Mar 25.
Hypoparathyroidism is one of the most important endocrine complications of thalassemia major. This study was conducted to evaluate the prevalence of intracerebral calcifications in patients with thalassemia with and without hypoparathyroidism.
47 beta-thalassemia patients with hypoparathyroidism underwent a brain CT scan to investigate the presence and extent of intracerebral calcification. 30 age- and sex-matched beta-thalassemic patients with normal parathyroid function who had undergone brain CT for headache, or some other minor neurologic problems were also enrolled in the study serving as controls. The amount of intracerebral calcification, hematologic parameters, and some clinical findings were compared between both groups.
Intracerebral calcification was present in 54.2% of beta-thalassemia patients with hypoparathyroidism. The most frequent sites of calcification were basal ganglia, and frontoparietal areas of the brain. Thalami, internal capsule, cerebellum and posterior fossa were other less frequently calcified regions of the brain. In contrast, there was no evidence of intracerebral calcifications in the 30 thalassemic patients with normal parathyroid function. There was not a statistically significant difference between serum ferritin concentrations in thalassemia patient with hypoparathyroidism and those with normal parathyroid function (2781 vs. 2178, P>0.05).
Intracranial calcification is a common finding in thalassemia patients with hypoparathyroidism, it can be extensive and involves most regions of the brain.
甲状旁腺功能减退是重型地中海贫血最重要的内分泌并发症之一。本研究旨在评估有无甲状旁腺功能减退的地中海贫血患者脑内钙化的发生率。
47例甲状旁腺功能减退的β地中海贫血患者接受脑部CT扫描，以调查脑内钙化的存在及程度。30例年龄和性别匹配、甲状旁腺功能正常、因头痛或其他轻微神经系统问题接受过脑部CT检查的β地中海贫血患者也纳入研究作为对照。比较两组脑内钙化量、血液学参数及一些临床发现。
54.2%的甲状旁腺功能减退的β地中海贫血患者存在脑内钙化。钙化最常见的部位是基底神经节和脑的额顶叶区域。丘脑、内囊、小脑和后颅窝是其他较少发生钙化的脑区。相比之下，30例甲状旁腺功能正常的地中海贫血患者没有脑内钙化的证据。甲状旁腺功能减退的地中海贫血患者与甲状旁腺功能正常的患者血清铁蛋白浓度之间无统计学显著差异（2781对2178，P>0.05）。
颅内钙化在甲状旁腺功能减退的地中海贫血患者中常见，可广泛存在并累及脑的大部分区域。
