Restrepo Berta Nelly, Isaza Diana María, Salazar Clara Lina, Ramírez Ruth, Ospina Marta, Alvarez Luis Gonzalo
Instituto Colombiano de Medicina Tropical-CES, Antioquia, Colombia.
Rev Soc Bras Med Trop. 2008 Jan-Feb;41(1):6-10. doi: 10.1590/s0037-86822008000100002.
This study compared the serum levels of IL-6, TNF-alpha and IFN-gamma, in children under 1 year of age with and without dengue. Sera were collected from a total of 41 children living in the Department of Antioquia, Colombia (27 patients with dengue and 14 controls). The results showed higher cytokine levels in children with dengue than without dengue, with statistically significant differences for IL-6 and IFN-gamma. No statistically significant differences were found between clinical forms, although IL-6 and IFN-gamma levels were higher in dengue fever cases than in dengue hemorrhagic fever cases. On the other hand, TNF-alpha levels were higher in dengue hemorrhagic fever than in dengue fever. The levels of IL-6 and TNF-alpha were higher in secondary infection than in primary infection, although IFN-gamma levels were higher in primary infection. These results suggest that IL-6, TNF-alpha and IFN-gamma are involved in dengue infection independently of the clinical form.
本研究比较了1岁以下患登革热和未患登革热儿童的血清白细胞介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）和干扰素-γ（IFN-γ）水平。共从哥伦比亚安蒂奥基亚省的41名儿童中采集血清（27例登革热患者和14名对照）。结果显示，患登革热儿童的细胞因子水平高于未患登革热的儿童，IL-6和IFN-γ有统计学显著差异。临床类型之间未发现统计学显著差异，尽管登革热发热病例的IL-6和IFN-γ水平高于登革出血热病例。另一方面，登革出血热的TNF-α水平高于登革热。继发感染时IL-6和TNF-α水平高于原发感染，而原发感染时IFN-γ水平更高。这些结果表明，IL-6、TNF-α和IFN-γ独立于临床类型参与登革热感染。
